# Cell Culture and iPS Core

> **NIH NIH P30** · UNIVERSITY OF PENNSYLVANIA · 2020 · $147,775

## Abstract

PROJECT SUMMARY (CELL CULTURE AND iPS CORE) 
The Cell Culture and iPS Core (CCiC) facility is unique on the University of Pennsylvania campus and in the 
region. It serves a tremendous need by Center of Molecular Studies in Digestive and Liver Diseases 
(abbreviated as CMSDLD, which is the NIDDK P30 Digestive Diseases Research Core Center) members for 
services and technologies underlying Specific Aims related to primary cells and established cell lines, 3D 
culture systems (organotypic culture and organoids), manipulating gene expression in cell lines through RNA 
interference and CRISPR/Cas9, and the application of induced pluripotent stem cells (iPS) that have been 
genetically reprogrammed to an embryonic stem cell-like condition and differentiating such cells to discrete 
lineages (GI, pancreas, liver). Furthermore, the CCiC provides a rich repository of c cell lines (2D and 3D) that 
are well annotated for identity, passage and free of Mycoplasma infection thereby providing quality control, 
rigor and reproducibility. The CCiC provides standardized protocols and regular orientation and instruction, 
which prove to be cost-effective measures. There are emerging projects related to the use of iPS technology to 
correct disease states in enteroids and hepatocytes, remarkable illustrations of translational medicine fueled by 
the CCiC. Through its services, technologies, quality control and time/cost-effectiveness, the CCiC advances 
the CMSDLD's vision and missions on behalf of members/associate members/personnel.

## Key facts

- **NIH application ID:** 9983075
- **Project number:** 5P30DK050306-24
- **Recipient organization:** UNIVERSITY OF PENNSYLVANIA
- **Principal Investigator:** EDWARD E MORRISEY
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $147,775
- **Award type:** 5
- **Project period:** 2020-07-01 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9983075

## Citation

> US National Institutes of Health, RePORTER application 9983075, Cell Culture and iPS Core (5P30DK050306-24). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9983075. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*