# Advanced Imaging and Instrumentation Core

> **NIH NIH U19** · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2020 · $417,912

## Abstract

Summary/Abstract (30 lines)
The mission of the Advanced Imaging and Instrumentation Core will be to deliver the necessary technical skill,
training and resources to enable the complex in-vivo research projects proposed. The current U19 proposal is
only possible thanks to very recent developments in in-vivo imaging, recording and manipulation techniques
that have enabled real-time studies in awake behaving mice. In particular, it is essential to leverage in-vivo,
awake measurement techniques to study motor control since one must be able to measure associated motor
output and task performance. Our Advanced Imaging and Instrumentation Core is composed of key experts in
the development and deployment of novel technologies, 2 of them BRAIN Initiative grant awardees. However,
it is important to note that the technologies to be deployed here will not require significant high-risk innovation,
but rather represent the integration and implementation of recently demonstrate breakthrough techniques for
rigorous application to studying motor circuits. These include 3-photon in-vivo functional microscopy, Adaptive
optics assisted photo manipulation, wide-field optical mapping and meso-scale two-photon microscopy. These
imaging methods will be combined with innovative surgical preparations, tasks, electrode recordings and
closed-loop strategies. Importantly, none of these technologies is available commercially, and thus the core will
need to ensure that these systems are quickly and effectively established and supported throughout the
duration of the project. Documentation of this development will be accompanied by adoption of ever evolving
new technologies as they become available. The Advanced Imaging and Instrumentation Core will also play an
important role in training and enabling researcher to adopt complex techniques, while working closely with the
Data Science Resource core on all aspects of data standardization, archiving, analysis and dissemination.
Overall, this core will represent a deep collaboration between experts in the development and deployment of
novel technologies, in collaboration with those leveraging the power of these important systems.

## Key facts

- **NIH application ID:** 9983205
- **Project number:** 5U19NS104649-04
- **Recipient organization:** COLUMBIA UNIVERSITY HEALTH SCIENCES
- **Principal Investigator:** Darcy S Peterka
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $417,912
- **Award type:** 5
- **Project period:** 2017-09-25 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9983205

## Citation

> US National Institutes of Health, RePORTER application 9983205, Advanced Imaging and Instrumentation Core (5U19NS104649-04). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9983205. Licensed CC0.

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