# Training in Translational Research in Alzheimer's and Related Dementias (TRIAD)

> **NIH NIH T32** · UNIVERSITY OF KENTUCKY · 2020 · $492,423

## Abstract

7. PROJECT SUMMARY/ABSTRACT
This is an application for a T32 training grant titled “Training in Translational Research in Alzheimer's Disease
and Related Dementias (TRIAD)” to support 4 predoctoral and 4 postdoctoral fellows. The overall goal of the
proposed program is to provide cross-disciplinary training from bench to bedside, to produce a new
translational workforce that is critically needed to develop and advance effective treatments for Alzheimer's
disease and related dementias. Trainees will receive rigorous and innovative translational research education
and training through a 3-cluster multidisciplinary and integrative mentoring program that spans the discovery
continuum from molecular/biochemical methods, preclinical translational approaches and clinical research. The
thematic focus is on risk factors for Alzheimer's disease and related dementias; these risk factors include
cerebrovascular disease, neuroinflammation, Down syndrome, and traumatic brain injury. The training program
has 18 faculty mentors with established and extensive interactions and collaborations, and successful track
records in training. The faculty mentors encompass diverse areas of expertise from cell & molecular biology,
genetics, and data science, through preclinical model systems, therapeutic development, neuroimaging,
neuropathology, clinical trials, and longitudinal clinical studies. The majority (13) of these mentors are housed
within the University of Kentucky Sanders Brown Center on Aging, which includes a long-standing NIA-funded
Alzheimer's Disease Center. All faculty with primary appointments in a Center also have academic
appointments in other basic science or clinical departments at the University of Kentucky. Predoctoral trainees
will be recruited from our Integrated Biomedical Sciences graduate program and from the MD/PhD program in
the College of Medicine, and postdoctoral trainees through targeted advertisement and recommendations from
colleagues and other Alzheimer's Disease Centers. In addition to their individualized research program and
career development plan, each group of trainees will participate in a series of educational experiences that
include a dedicated AD101 course in Alzheimer's disease and related dementias, seminars describing
research and clinic ethics, monthly research and career development seminars, journal clubs, Training the
Trainers workshops, and grant writing workshops. Each year trainees will be expected to present their
research at the annual Markesbery Symposium on Aging and Dementia. Postdoctoral trainees will be provided
with additional training opportunities, including: 1) a short off-site externship at another laboratory that conducts
Alzheimer's disease research and 2) presentations at the annual College of Medicine Postdoctoral Poster
Session. Quantitative and qualitative metrics for evaluation of trainees and the training program will assure a
high-quality and effective training experience. The outcomes of our pr...

## Key facts

- **NIH application ID:** 9983527
- **Project number:** 5T32AG057461-04
- **Recipient organization:** UNIVERSITY OF KENTUCKY
- **Principal Investigator:** Michael Paul Murphy
- **Activity code:** T32 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $492,423
- **Award type:** 5
- **Project period:** 2017-09-15 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9983527

## Citation

> US National Institutes of Health, RePORTER application 9983527, Training in Translational Research in Alzheimer's and Related Dementias (TRIAD) (5T32AG057461-04). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9983527. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*