# Training program in the biology and translational research on Alzheimer's disease and related dementias

> **NIH NIH T32** · UNIVERSITY OF ILLINOIS AT CHICAGO · 2020 · $205,166

## Abstract

ABSTRACT
This T32 application seeks support for the multidisciplinary education of trainees in Alzheimer's disease and
related dementia (ADRD). Neuroscience, including Basic Biology of molecular and cellular mechanisms of
aging, epigenetics and gender, is the core of the ADRD training program (ADRD-TP). However, the program
will include Drug Discovery and Development, Clinical and Translational Research including entrepreneurship,
and Bioinformatics, Biophysics and Data Science. The mentor/preceptor team has outstanding expertise to
establish this innovative, interdisciplinary training program, to integrate otherwise disparate centers of
excellence at UIC and Rush, leveraged by industry collaborations. It will provide training in the emerging,
multidisciplinary understanding of neurodegeneration and dementia, that trainees need to reinvigorate the
search for treatments and cures. We will answer the imperative need for scientists who can synthesize across
disciplines. Preceptor expertise is diverse; from molecular mechanisms of dementia, vascular biology, diabetes
and inflammation, neuronal and neural imaging to clinical diagnosis of human ADRD patients and large scale
data analysis. Expertise is from 11 departments (Anatomy and Cell Biology, Neurology, Psychiatry, Medicine,
Pharmacology, Anesthesiology, Bioengineering, Computer science, Medicinal Chemistry, Chemistry, and
Kinesiology) 5 colleges (Medicine, Pharmacy, Engineering, Liberal Arts, Applied health sciences), 5 clinical
and translational entities (The Alzheimer's Disease Research Center at Rush, the Aging and Memory Clinic at
UIC, the UIC tissue repository bank and the Center for Research on Health and Aging at UIC, the Center for
Clinical Translation Science (CCTS) at UIC). We will train ADRD researchers with diverse backgrounds and
cross-disciplinary skills, including neuroscientists, but also computational biologists, and engineers interested
in translational ADRD research. To facilitate interdisciplinary training, trainees will have a primary preceptor
and secondary mentor; the latter utilizing skills of associates from many disciplines. We will build individual
development plans (IDPs) for each trainee and offer multidisciplinary coursework from ADRD-TP faculty but
also pharma scientists. Importantly, trainees can perform translational research at 1 of 4 affiliated clinical and
translational entities. Trainees will be encouraged to collaborate with large community-based NIH-supported
studies (ROS/MAP or NIA's large-scale collaborative consortia, AMP-AD, M2OVE-AD, ADNI, ACTC), and with
our industry partners, Eli Lilly and AbbVie. Trainees are encouraged to participate in workshops of the CCTS,
the Chicago Biomedical Consortium (CBC) that is geared towards -omics and drug discovery and the
CIM/MATTER entrepreneurial program that aids commercialization of scientific innovation. We seek to support
4 graduate students. With the trainee's mentors and utilizing IDPs, progress will be monit...

## Key facts

- **NIH application ID:** 9983531
- **Project number:** 5T32AG057468-04
- **Recipient organization:** UNIVERSITY OF ILLINOIS AT CHICAGO
- **Principal Investigator:** Orly Lazarov
- **Activity code:** T32 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $205,166
- **Award type:** 5
- **Project period:** 2017-09-15 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9983531

## Citation

> US National Institutes of Health, RePORTER application 9983531, Training program in the biology and translational research on Alzheimer's disease and related dementias (5T32AG057468-04). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9983531. Licensed CC0.

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