# Predicting patient-reported outcomes in patients with pre-arthritic hip disorders

> **NIH NIH K23** · WASHINGTON UNIVERSITY · 2020 · $165,464

## Abstract

PROJECT SUMMARY / ABSTRACT
Dr. Abby L Cheng, MD, is a sports medicine physiatrist with a background in biomedical engineering whose
research goal is to develop and implement a comprehensive, evidence-based management algorithm for
patients with pre-arthritic hip disorders (PAHD). Her educational, clinical, and research experiences uniquely
prepare her to pursue this work, and this career development award will facilitate the complementary
epidemiological training she requires, with an emphasis on risk prediction modeling, bioinformatics, clinical
trials, and dissemination and implementation research. All research and training activities will occur at the
Washington University School of Medicine, an institution with a strong health services research program and a
multidisciplinary hip research group. PAHD are bony and soft tissue hip morphologies that predispose
adolescents and young adults to developing hip pain, chronic impairment, and early osteoarthritis (OA). Proper
management may prevent these sequelae, but current evidence, especially regarding non-operative treatment
options, is limited. To address this need, the purpose of this project is to identify predictors of response to non-
operative PAHD treatment options and to synthesize these predictors into a clinical prediction tool that informs
non-operative one-year outcomes using data available during patients’ initial evaluation. Aim 1 is a
retrospective analysis that will quantify associations between PAHD patients’ one-year clinical outcomes and
their baseline clinical characteristics, Patient-Reported Outcomes Measurement Information System (PROMIS)
scores, and hip-specific “legacy” patient-reported outcome measure (PROM) scores. The analysis will also
determine a minimum combination of PROMIS and legacy PROM measures that reduces survey burden while
maintaining similar predictive utility when compared to administration of all currently collected legacy and
PROMIS measures. Aim 2 will be a prospective study to identify predictors of PAHD patient adherence and
symptom response to eight weeks of therapeutic activity modification. Activity modification is a conservative
treatment that addresses how patients perform routine and strenuous activities in order to reduce hip pain. It
has proven to be efficacious in a randomized trial setting, but it is not yet widely discussed by physicians in the
clinic setting. Finally, Aim 3 will be a prospective study to develop a clinical prediction tool that determines
PAHD patients’ risk of chronic impairment or progression to surgery at one year follow-up and identifies
potentially modifiable predictors. Patients’ demographics, biopsychosocial profile, movement and activity
patterns, and anatomy will be considered as predictors. Completing the aims and mentored training outlined in
this career development award will prepare Dr. Cheng to create, validate, and implement patient-centered,
evidence based treatment models which yield quicker pain relief, im...

## Key facts

- **NIH application ID:** 9983598
- **Project number:** 5K23AR074520-02
- **Recipient organization:** WASHINGTON UNIVERSITY
- **Principal Investigator:** Abby Ling-Lee Cheng
- **Activity code:** K23 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $165,464
- **Award type:** 5
- **Project period:** 2019-08-01 → 2024-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9983598

## Citation

> US National Institutes of Health, RePORTER application 9983598, Predicting patient-reported outcomes in patients with pre-arthritic hip disorders (5K23AR074520-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9983598. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*