# Effects of Prenatal and Early Life Exposures on the Microbiome in American Indian Children.

> **NIH NIH P20** · SANFORD RESEARCH/USD · 2020 · $294,062

## Abstract

Project Summary/Abstract 
American Indian (AI) children have high rates of chronic disease development including asthma, obesity and 
type 2 diabetes. The intestinal microbiome is a potential common contributor to all of these, yet no research 
currently exists examining the intestinal microbiome in AI children as a possible link to chronic disease 
development. This proposal includes several analyses to assess the contribution of race as well as prenatal 
exposures and early childhood environment to the colonization of the intestinal microbiome as well as possible 
links to chronic disease risk factors. The microbiome will be assessed both shortly after birth using stored 
meconium samples and again at three years of age. Longitudinal samples will help to delineate long term 
effects of prenatal exposures from effects of the early life environment and racial background. In addition to its 
relationship to exposures, this proposal will also explore links between the intestinal microbiome and risk 
factors for chronic disease, providing information about possible intervention strategies in at-risk populations. 
This is especially important for AI children as the risk for development of chronic disease is elevated and 
current prevention efforts have not achieved a reduction in risk. Thus, there is an urgent need to develop 
models to better understand how exposures relate to biological markers that can be used for disease 
prediction and intervention development.

## Key facts

- **NIH application ID:** 9983761
- **Project number:** 5P20GM121341-04
- **Recipient organization:** SANFORD RESEARCH/USD
- **Principal Investigator:** Arielle R. Deutsch
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $294,062
- **Award type:** 5
- **Project period:** — → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9983761

## Citation

> US National Institutes of Health, RePORTER application 9983761, Effects of Prenatal and Early Life Exposures on the Microbiome in American Indian Children. (5P20GM121341-04). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/9983761. Licensed CC0.

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