# DNA Damage and Repair Core

> **NIH NIH P01** · OREGON HEALTH & SCIENCE UNIVERSITY · 2020 · $180,415

## Abstract

CORE C PROJECT SUMMARY:
The primary goal of the program is to assess novel therapeutic candidates in preclinical models of Fanconi
anemia (FA). The specific objective of Core C is to systematically evaluate the activity of those FA candidate
therapeutic agents in modulating DNA damage response (DDR) and DNA repair using cell-based and
biochemical assays. Accordingly, Core C will provide a variety of DDR and DNA repair assay services to the
investigators in Projects 1-3. The specific aims of Core C are: 1) Systematically evaluate the activity of FA
therapy small molecule candidates in DDR assays and DNA repair assays, 2) Collect FA cell lines for all in
vitro assays, 3) Integrate the data collected by Core C with the data collected by projects 1-3, and 4) Generate
publication-grade data for the project and core leaders.

## Key facts

- **NIH application ID:** 9983796
- **Project number:** 5P01HL048546-25
- **Recipient organization:** OREGON HEALTH & SCIENCE UNIVERSITY
- **Principal Investigator:** Kalindi Tapubhai Parmar
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $180,415
- **Award type:** 5
- **Project period:** — → 2022-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9983796

## Citation

> US National Institutes of Health, RePORTER application 9983796, DNA Damage and Repair Core (5P01HL048546-25). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9983796. Licensed CC0.

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