PROJECT SUMMARY/ABSTRACT The Clinical Translation Core (CTC) supports the UNC RTCC by providing access to human biospecimens, clinical research expertise (including biostatistics, bioinformatics, trial design, and regulatory assistance) and specialized clinical research outcome measures. These functions have supported more than 40 investigators and the conduct of many research studies. In the current application, the CTC focus will shift its focus to research aimed at defining the pathophysiologic basis of GI symptoms and complications in people with cystic fibrosis. Toward this end, new partnerships with experts in GI biology and disease have been formed to meet these scientific challenges. Strategies that maximize capture of precious human samples during both clinically indicated and research procedures will be implemented. Ongoing biostatistical and study design support will be provided, while also continuing to maintain previously developed core functions that support respiratory research.