# Improving spatiotemporal precision in noninvasive electrical neuromodulation

> **NIH NIH R44** · BRAIN ELECTROPHYSIOLOGY LABORATORY COMPANY, LLC · 2020 · $298,843

## Abstract

This application describes the commercialization of the Geodesic Transcranial Electrical Neuromodulation
(GTEN) technology to achieve noninvasive neuromodulation with improved spatiotemporal precision. The
GTEN system enables both EEG source analysis and configurable electrical neuromodulation with the 256
electrodes of the Geodesic Sensor Net. Now in beta release to selected research customers, the GTEN
technology will be fully commercialized as a medical device through addressing four specific aims guided by
the goals for noninvasive neuromodulation in the BRAIN Initiative. (1) We will improve focal current delivery at
deep as well as superficial brain locations with a novel targeting algorithm (Discriminative Cortical Source
Vectoring) implemented with a high resolution conductivity model of the human head. (2) Both simulation and
experiment will be used to minimize extraneous stimulation to non target regions while quantifying current
delivered to all brain regions. (3) We will design and test a placebo mode to allow definitive clinical trials. (4)
Closed loop operation will be achieved by guiding the localization and phase of GTEN intervention with
simultaneous monitoring of source-localized EEG. In the validation of closed-loop operation, the EEG rhythms
will be those of slow wave sleep, and they will be hypothesized to be enhanced in both depth and length during
the night's sleep. Completing the aims of this SBIR will create a dEEG-guided noninvasive dense array
electrical neuromodulation technology as a powerful, precise, and inexpensive technology for both research
and clinical practice.

## Key facts

- **NIH application ID:** 9984100
- **Project number:** 3R44MH115955-02S1
- **Recipient organization:** BRAIN ELECTROPHYSIOLOGY LABORATORY COMPANY, LLC
- **Principal Investigator:** Don M Tucker
- **Activity code:** R44 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $298,843
- **Award type:** 3
- **Project period:** 2019-01-23 → 2021-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9984100

## Citation

> US National Institutes of Health, RePORTER application 9984100, Improving spatiotemporal precision in noninvasive electrical neuromodulation (3R44MH115955-02S1). Retrieved via AI Analytics 2026-06-11 from https://api.ai-analytics.org/grant/nih/9984100. Licensed CC0.

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