# Comprehensive Assessment of Right Ventricular and Pulmonary Vascular Function via CT Imaging in Heart Failure Patients

> **NIH NIH K01** · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2020 · $160,384

## Abstract

Project Summary:
Mechanical circulatory support is required by a large percentage of patients who undergo heart transplant and
serves as a destination therapy for end-stage heart failure patients who are ineligible for transplant. However,
clinicians are currently unable to predict the up to 40% of patients who develop right heart failure after
receiving left ventricular assist devices. If identified pre-operatively, these patients could receive planned
biventricular support which has been shown to improve outcomes. Unfortunately, pre-operative hemodynamic
parameters, echocardiographic measures, and clinical risk scores have shown limited effectiveness in
identifying these patients. The hypothesis of this project is that load-independent measures of
ventricular function and assessment of ventricular-arterial coupling are necessary to improve
prediction of right heart function and failure in patients receiving left ventricular assist devices.
To investigate this hypothesis, we will develop and validate novel CT-based techniques which allow for
comprehensive and simultaneous assessment of the right ventricle and pulmonary arteries in a single
heartbeat. By acquiring these novel measures along with gold-standard estimates in clinical patients, we will
validate whether measures of ventricular-arterial coupling can be obtained with cineCT. Furthermore, acquiring
multi-modality images in clinical patients undergoing left ventricular assist device implantation will allow for
assessment of whether measures of ventricular-arterial coupling provide clinically predictive information
regarding post-implantation right ventricular function (and failure).
The proposal includes a training plan designed to address gaps in the applicant’s technical and professional
experiences and help launch his independent research career. Specifically, the training includes: didactic
coursework in biostatistics, patient-oriented research, and grant writing, training in navigating the academic
work environment, mentorship in multi-modality imaging and pulmonary vascular physiology, clinical exposure
to the management and treatment of heart failure patients, exposure to potential graduate students through
teaching of imaging-focused coursework, and increased exposure to the international research community via
publications and attendance and presentations at annual meetings. UC San Diego is the optimal environment
for this award. In addition to support by world-class facilities and collaborators in the Bioengineering,
Radiology, and Cardiology departments, the applicant and research proposal will have a very high probability
of success given the benefit of and access to campus-wide resources such as the Altman Clinical and
Translational Research Institute and Institute for Engineering in Medicine.

## Key facts

- **NIH application ID:** 9984516
- **Project number:** 5K01HL143113-03
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN DIEGO
- **Principal Investigator:** Francisco J Contijoch
- **Activity code:** K01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $160,384
- **Award type:** 5
- **Project period:** 2018-08-01 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9984516

## Citation

> US National Institutes of Health, RePORTER application 9984516, Comprehensive Assessment of Right Ventricular and Pulmonary Vascular Function via CT Imaging in Heart Failure Patients (5K01HL143113-03). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/9984516. Licensed CC0.

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