# Fourth EU-US Workshop on Nucleotide excision repair and crosslink repair - from molecules to mankind

> **NIH NIH R13** · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2020 · $7,000

## Abstract

R13 Title: Fourth EU-US Workshop on `Nucleotide excision repair and crosslink repair –
from molecules to mankind.
PI: Bennett Van Houten
Abstract:
We will address the state-of-the-art scientific progress for two closely related critical pathways:
nucleotide excision repair (NER) and crosslink repair. Disruption of these pathways is associated
with devastating heritable human conditions including: severe developmental abnormalities,
cancer, bone marrow failure, neurodegeneration and premature aging. A large number of
environmental insults both man-made and natural can cause DNA damage which is repaired
through these two pathways. Moreover, for patients undergoing cancer treatment, DNA repair
enzymes can counteract the efficiency of many important antitumor drugs and DNA repair
enzymes constitute compelling, but underexplored, targets for drug design. The Workshop will
frame the current state of the science and also articulate where the scientific direction for the field
as current technical and scientific hurdles are overcome. The Workshop will move from molecular
science to human biology exploring the basis of disease syndromes associated with defects in
NER and crosslink repair as well as investigating strategies to inhibit these enzymes. The
Workshop will provide an unparalleled forum for young scientists, including those from central
and eastern Europe, to meet and engage with scientists from the EU and globally who are driving
the field. The main goals of this workshop are to: 1) highlight the state of the science and current
technologies being used to study this problem; 2) exchange ideas between scientists in the EU
and US; and 3) provide a forum that allows scientists in the local region an opportunity to meet
and engage with scientists from the EU and US who are driving the field.

## Key facts

- **NIH application ID:** 9984688
- **Project number:** 1R13ES031835-01
- **Recipient organization:** UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- **Principal Investigator:** Bennett Van Houten
- **Activity code:** R13 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $7,000
- **Award type:** 1
- **Project period:** 2020-04-01 → 2022-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9984688

## Citation

> US National Institutes of Health, RePORTER application 9984688, Fourth EU-US Workshop on Nucleotide excision repair and crosslink repair - from molecules to mankind (1R13ES031835-01). Retrieved via AI Analytics 2026-06-12 from https://api.ai-analytics.org/grant/nih/9984688. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*