# Regulation of Inflammation and Atherosclerosis by TCF21

> **NIH NIH K08** · STANFORD UNIVERSITY · 2020 · $168,048

## Abstract

PROJECT SUMMARY
This five-year K08 proposal will provide the candidate, Juyong Brian Kim, with rigorous training to fulfill specific
needs in research and professional development and successfully launch his independent physician-scientist
career. The long-term goals are to prepare the candidate for a life-long career as a physician-scientist focused
on atherosclerosis and to ultimately improve the management of patients with atherosclerosis through the
development of novel therapeutics.
The candidate's primary mentor is Dr. Thomas Quertermous, who is an internationally renowned expert in
high-throughput genetics, transcriptional regulatory mechanisms, and vascular biology. The candidate is also
supported by a committee of advisors and collaborators with expertise in vascular biology and disease,
epigenetics and genomics (Drs. William Greenleaf, Gary Owens, Marlene Rabinovitch, Phil Tsao, and Sean
Wu). Collectively, the candidate, mentor and advisory committee have formulated a career development plan
that will: i) develop the candidate's scientific background for successful research in an important area that
parallels his clinical interests; ii) facilitate the candidate's acquisition of new technical skills in cellular and
molecular biology and genetics; and iii) provide a mentored transition period between postdoctoral training and
independent investigation. The training plan consists of dedicated research time, attendance at meetings to
present original work, leadership development, attendance of academic seminars, lectures and journal clubs,
formal and informal meetings with the mentor and advisory committee, as well as formal training in the
responsible conduct of research. All key personnel have vast experience in the mentorship of trainees.
Additionally, Stanford University is committed to providing a maximally supportive environment for the
candidate's career development. The candidate will have all resources, infrastructure and support in place to
ensure success. The candidate has newly renovated and well equipped laboratory space, the support of
clinical colleagues and support staff to ensure at least 80% of his time is protected for research and the
support of an abundance of core facilities and shared resources offered through the School of Medicine and
through the laboratories of the mentor and advisory committee. Stanford University provides the ideal
environment for the candidate's career development.
The research topic of this proposal fulfills a significant knowledge gap in the field by identifying a novel
mechanism leading to smooth muscle cell inflammation and plaque instability in atherosclerotic lesions.
Atherosclerosis is a genetically complex trait that claims more lives than cancer, lung disease and accidents
combined. The candidate proposes several hypothesis-driven approaches that will address critical gaps in
understanding the genetic basis of atherosclerosis. In Specific Aim 1, the candidate will define the function of...

## Key facts

- **NIH application ID:** 9984838
- **Project number:** 5K08HL133375-05
- **Recipient organization:** STANFORD UNIVERSITY
- **Principal Investigator:** Juyong Brian Kim
- **Activity code:** K08 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $168,048
- **Award type:** 5
- **Project period:** 2016-08-01 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9984838

## Citation

> US National Institutes of Health, RePORTER application 9984838, Regulation of Inflammation and Atherosclerosis by TCF21 (5K08HL133375-05). Retrieved via AI Analytics 2026-05-29 from https://api.ai-analytics.org/grant/nih/9984838. Licensed CC0.

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