# Deciphering the Neonatal Cardiac Regenerative Potential and Regulators in Large Animals

> **NIH NIH R01** · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2020 · $624,149

## Abstract

ABSTRACT
Heart failure is a costly and deadly disease affecting over 5 million Americans. The inability of the adult
mammalian heart to regenerate following injury lies at core of the pathophysiology of heart failure. We recently
showed that the neonatal mammalian heart is capable of complete regeneration in the first few days of life
following various types on injury. Despite the important implications to human heart disease, it is remains unclear
whether larger mammals or humans have this regenerative potential, a phenomenon that would have significant
mechanistic and therapeutic implications for pediatric as well as adult heart disease. In the current proposal, we
will examine whether a similar cardiac regenerative potential exists in large mammals, outline the duration of this
regenerative window, and decipher the regulators that controls myocyte cell cycle. In addition, we will examine
whether we can modify these key regulators to control the myocytes cell cycle for remuscularization of hearts
with myocardial infarction.

## Key facts

- **NIH application ID:** 9984841
- **Project number:** 5R01HL149137-02
- **Recipient organization:** UNIVERSITY OF ALABAMA AT BIRMINGHAM
- **Principal Investigator:** Hesham Sadek
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $624,149
- **Award type:** 5
- **Project period:** 2019-07-15 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9984841

## Citation

> US National Institutes of Health, RePORTER application 9984841, Deciphering the Neonatal Cardiac Regenerative Potential and Regulators in Large Animals (5R01HL149137-02). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/9984841. Licensed CC0.

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