# Mobile Assessment of Behavioral and Psychological Symptoms of Dementia in Adults with Alzheimer's Disease

> **NIH NIH K23** · INDIANA UNIVERSITY INDIANAPOLIS · 2020 · $178,790

## Abstract

PROJECT SUMMARY/ABSTRACT:
 In 2018, an estimated 5.7 million Americans live with Alzheimer's disease (AD), with as many as 98%
experiencing behavioral and psychological symptoms of dementia (BPSD). BPSD negatively impacts AD
patients' and their caregivers' quality of life, results in earlier institutionalization and increases costs of care. Most
approaches to assessment of BPSD rely on survey-based clinical scales completed by the caregiver during a
clinic visit, such as the neuropsychiatric inventory questionnaire (NPI-Q). Recall bias and reporting of symptoms
outside of the home, where symptoms occur, negatively impacts the accuracy of these scales. Accurate
appraisal of BPSD is needed to apply the right treatment at the right time.
 This proposal outlines a career development plan to assist Dr. Bateman in becoming a patient-oriented
AD researcher with specialization in innovative, technology-based measurement and intervention design. This
career award will provide him with the needed research skills, knowledge and experience to become an
independent investigator with expertise in BPSD and strengths in leveraging mobile health technologies to
improve the lives of persons with AD. This will be accomplished through participation and completion of course
work, mentorship interactions, practical research training activities, and an original research project to improve
BPSD and caregiver distress measurement. This project utilizes smartphone-based ecological momentary
assessment (EMA) delivery of the NPI-Q to AD caregivers (NPIQ-EMA). EMA is a group of methods that
incorporate repeated sampling of participants by the asking questions of subjects in a real-time and real-
environment. The proposed project is a randomized phase 2 clinical trial where AD patient-caregiver dyads
receiving care from the Healthy Aging Brain Center (HABC) program at Eskenazi Health will be recruited and
randomized to either an intervention group receiving the 6 month long NPIQ-EMA intervention and usual care
in the HABC program or a control group receiving usual care (HABC program) alone with primary outcomes of
feasibility and usability. Recruitment will take place at Eskenazi Health, one of the nation's largest safety net
hospitals. Dr. Bateman's project will profit from the Indiana University Center of Aging Research (IUCAR)
expertise in AD intervention trials, mobile health research, and analysis. Dr. Bateman and his mentorship team
designed a career development to ensure his successful transition into an independent, investigator in AD
research. This plan incorporates 1) participation in a master in clinical research program that emphasizes
biostatistics, ethical research conduct, research methods, and effective grant writing; 2) mentorship; 3)
practical research training; 4) extramural training; and 5) leveraging of a nationally recognized research
environment at Indiana University. Completion of this training plan and research project will help Dr. Bateman
develop in...

## Key facts

- **NIH application ID:** 9984925
- **Project number:** 5K23AG059914-02
- **Recipient organization:** INDIANA UNIVERSITY INDIANAPOLIS
- **Principal Investigator:** Daniel Bateman
- **Activity code:** K23 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $178,790
- **Award type:** 5
- **Project period:** 2019-08-01 → 2021-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9984925

## Citation

> US National Institutes of Health, RePORTER application 9984925, Mobile Assessment of Behavioral and Psychological Symptoms of Dementia in Adults with Alzheimer's Disease (5K23AG059914-02). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/9984925. Licensed CC0.

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