# Cellular and Molecular Defects in Human B Cell Development

> **NIH NIH P01** · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2020 · $2,130,985

## Abstract

Abstract
Primary immune deficiency diseases (PIDs), now at well over 250 different defects, have provided a
remarkable resource for investigators in human immunology. The study of human PIDs has made possible
some of the most exciting advances in immunology today. With the accelerated pace of work in human
diseases, it is clear that many more immune defects will be discovered in the next few years, each of which
can illuminate essential components of human immunity. While there have been amazing advances in the
understanding of many of these conditions, the pathogenesis of the more common immune defects, those
which impair B cell function, are still largely uncharted territory. These diseases include the common and
heterogeneous conditions, common variable immune deficiency, selective IgA deficiency, IgG subclass and
specific antibody deficiency. This application is for a competitive renewal to provide continued Program
Project support for a stellar, energetic, and highly collaborative research group that focuses on these
diseases. The advantageous and efficient use of these rare human resources is best accomplished by a
Program Project approach, in which a medical center with an established program in the diagnosis and
treatment of a wide range of patients, is able to coordinate and support the collective work of a group of
integrated and dedicated investigators who have devoted their careers to the study of human immunology
and PIDs. This group of investigators located in the NYC area has been drawn together by shared synergy,
enthusiasm, and passion for this field. Our established collaborations, with a proven track record of
ongoing accomplishments, attest to the advantages, even the necessity of this approach.

## Key facts

- **NIH application ID:** 9984932
- **Project number:** 5P01AI061093-16
- **Recipient organization:** ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- **Principal Investigator:** CHARLOTTE CUNNINGHAM-RUNDLES
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $2,130,985
- **Award type:** 5
- **Project period:** 2004-07-01 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9984932

## Citation

> US National Institutes of Health, RePORTER application 9984932, Cellular and Molecular Defects in Human B Cell Development (5P01AI061093-16). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9984932. Licensed CC0.

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