# Translational Laboratory Shared Service

> **NIH NIH P30** · UNIVERSITY OF MARYLAND BALTIMORE · 2020 · $66,460

## Abstract

7.0 Abstract: Translational Laboratory Shared Service
The Translational Laboratory Shared Service (TLSS) at UMGCC generates preclinical (cell- and animal-based)
and clinical data for investigators to support cutting-edge research and provides preliminary data for grant
submissions and letters of intent for Phase I/II clinical trials, which is a major thrust of TLSS activity. The TLSS
also develops in vitro and in vivo preclinical models for evaluation of novel anticancer agents to translate
scientific ideas into therapeutics. The TLSS supports many Phase I/II clinical trials at UMGCC by isolating
biological specimens and developing and executing assays for correlative studies to support these trials. The
TLSS is unique in that it provides a combination of services and resources usually not offered by any one core,
predominantly supporting physicians engaged in clinical and translational research and preclinical
investigators, fellows, and students conducting preclinical in vivo studies.
The TLSS supports Phase I/II clinical trials, provides access to in vivo tumor models, generates preliminary
data for grant applications, supports submission of patent applications, and generates data that provide the
basis for new clinical trial protocols. These efforts have resulted in publications that include TLSS staff as
coauthors, clearly demonstrating the positive impact the TLSS has on cancer research at UMGCC. Since
2010, the TLSS has provided support for 27 clinical trials, including providing preliminary data for 4 new
investigator-initiated trials; carried out over 200 animal experiments through an umbrella animal protocol that
streamlines investigators’ access to animal studies; and provided preliminary data to 8 peer-reviewed, funded
grant applications.
In 2014, the TLSS supported 46 Cancer Center members spanning all 5 research programs (18 percent of all
UMGCC members), 63 percent of whom have peer-reviewed funding. The TLSS supports many cancer-related
publications annually, many in high-impact journals including Nature Communications and Clinical Cancer
Research.

## Key facts

- **NIH application ID:** 9984990
- **Project number:** 5P30CA134274-13
- **Recipient organization:** UNIVERSITY OF MARYLAND BALTIMORE
- **Principal Investigator:** Rena Lapidus
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $66,460
- **Award type:** 5
- **Project period:** 2008-08-08 → 2021-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9984990

## Citation

> US National Institutes of Health, RePORTER application 9984990, Translational Laboratory Shared Service (5P30CA134274-13). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9984990. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*