# Molecular and Structural Biology (MSB)

> **NIH NIH P30** · UNIVERSITY OF MARYLAND BALTIMORE · 2020 · $50,863

## Abstract

15.0 Abstract: Molecular and Structural Biology Program 
The overarching goals of the Molecular and Structural Biology (MSB) Program of UMGCC are to elucidate 
molecular mechanisms and cellular processes that are altered in cancer and to encourage translation of these 
basic scientific findings toward the development of novel strategies for treating cancer. To achieve these goals, 
the program focuses on three themes: Theme 1: DNA repair and checkpoint signaling—characterizing 
defects in DNA repair and checkpoint signaling and understanding how these defects impact cancer 
development; Theme 2: Inappropriate gene expression—determining how defects in transcriptional and 
posttranscriptional processes lead to inappropriate regulation of protein expression in cancer; and Theme 3: 
Oncogenes and tumor suppressors—delineating how signaling pathways (i.e., oncogenic, tumor 
suppressor, etc.) are deregulated in cancer and identifying specific biomolecules that can be targeted to 
reverse these effects. 
The MSB Program has 50 members representing 16 academic departments and 6 schools of the University of 
Maryland. Members of the program conduct cancer-focused research that receives $6.78 million total annual 
funding, including $2.34 million from NCI and $3.58 million from other peer-reviewed sources. In addition, the 
MSB Program members receive over $0.86 million annually from non-peer-reviewed funding sources. Between 
January 2010 and December 2014, MSB members authored 664 cancer-related publications, of which 13 
percent resulted from intraprogrammatic and 18 percent from interprogrammatic collaborations. Approximately 
48 percent of the publications represent collaborations with external investigators. Research efforts by MSB 
faculty are supported by extensive use of the SBSS, FCSS, TLSS, PBSS, ISS, and BSS.

## Key facts

- **NIH application ID:** 9984999
- **Project number:** 5P30CA134274-13
- **Recipient organization:** UNIVERSITY OF MARYLAND BALTIMORE
- **Principal Investigator:** DAVID S WEBER
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $50,863
- **Award type:** 5
- **Project period:** 2008-08-08 → 2021-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9984999

## Citation

> US National Institutes of Health, RePORTER application 9984999, Molecular and Structural Biology (MSB) (5P30CA134274-13). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/9984999. Licensed CC0.

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