# Core A: Animals Models-Stoltz

> **NIH NIH P01** · UNIVERSITY OF IOWA · 2020 · $713,297

## Abstract

CORE A – ANIMAL MODELS
PROJECT SUMMARY
Cystic fibrosis (CF) is a common autosomal recessive disease caused by mutations in the gene encoding the
cystic fibrosis transmembrane conductance regulator (CFTR). CF affects multiple organs, including lungs,
pancreas, intestine, liver, sweat glands, gallbladder and the male genital tract. Airway infection and
inflammation currently cause most of the morbidity and mortality. Although several therapies have improved
the lives of patients, current treatments are inadequate and CF remains a lethal disease. Our knowledge
about the pathogenesis of the disease, its progression, and the state of the neonatal lung is inadequate.
These gaps in our knowledge have hindered attempts to develop better treatments and preventions for CF
lung disease. A major impediment to addressing these issues had been limitations of animal models. We
generated CF pigs that replicate many of the key features of human CF disease including intestinal
obstruction, exocrine pancreatic destruction, micro-gallbladder, vas deferens abnormalities, focal biliary
cirrhosis, congenital airway structural abnormalities, and airway and sinus infection with time. The goals of the
Animal Models Core will be to (1): Provide Program investigators with non-CF and CF pigs so that they can
successfully complete their project aims; (2) Build new genetically engineered CF pig models; (3) Assist
projects in the harvesting of biologic samples from live animals (e.g., bronchoalveolar lavage fluid and blood),
the care and analysis of study animals, record keeping, and coordinate animal usage among projects. The
Animal Models Core will function seamlessly through already established interactions with the Project Leaders
and Core Directors. The success of the Animal Models Core is ensured because of the commitment,
experience, and expertise that the personnel bring to the Core.

## Key facts

- **NIH application ID:** 9985166
- **Project number:** 5P01HL091842-13
- **Recipient organization:** UNIVERSITY OF IOWA
- **Principal Investigator:** DAVID A STOLTZ
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $713,297
- **Award type:** 5
- **Project period:** 2008-09-05 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9985166

## Citation

> US National Institutes of Health, RePORTER application 9985166, Core A: Animals Models-Stoltz (5P01HL091842-13). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9985166. Licensed CC0.

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