# 2020 DNA Damage, Mutation and Cancer GRC/GRS

> **NIH NIH R13** · GORDON RESEARCH CONFERENCES · 2020 · $7,000

## Abstract

Summary
The goal of the 2020 GRC and GRS on DNA Damage, Mutation and Cancer is to stimulate research through
scientific dialog on the genomic changes and cellular responses that underlie cancer susceptibility. The GRS
will be from February 29-March 1, 2020 and the GRC will follow on March 1-6, 2020, both at the Ventura Beach
Marriott in Ventura, CA. The GRC takes place at a period when interest in DNA damage, its genomic impact,
relationship to cancer, and exploiting DNA damage susceptibilities to develop new therapies is at an all-time
high. Not only does this field provide critical insight to the consequences of DNA damage for genome integrity
and cancer avoidance, but also genome editing requires understanding and manipulating DNA repair, and the
opportunity to treat cancer with novel checkpoint inhibitors is bolstered by underlying defects in DNA repair and
replication stress responses. DNA damage occurs during replication and also during other cell cycle phases
though base modifications, adducts, DNA nicks and breaks, aberrant DNA structures, and other causes. The
impact of DNA damage is far reaching, inducing an inflammatory response, a checkpoint response, and
mutation. Understanding causes of mutation, consequences of mutation at the genome level and how this
translates into cancer risk, and exploiting DNA damage responses are goals of these meetings.
The GRS has invited talks and talks chosen from abstracts based on new findings and impact of the research.
There will be a mentorship session, with presentations from early and midcareer scientists, scientists from
industry and the publishing sector. The GRC has speakers from an international makeup, representing
academia, industry and physician scientists. There will be a mix of senior, midcareer and early investigators.
The GRS will have poster sessions each day to stimulate individual interactions and to meet trainees. Some
poster presenters will be chosen for late-breaking short talks. The Power Hour afternoon session will discuss
challenges to women in science, challenges to minorities in science, and establish new networking interactions.
At some of the dinners there will be theme tables, one night based on scientific topics and another night based
on mentoring and career options, to encourage participation of students and postdocs and to help interactions
between these groups and senior scientists.
Many of the speakers are new to this conference and the Gordon conferences. There are 3/6 females among
the invited participants for the GRS and 12/33 females among the invited participants for the GRC. Nine
speakers are at the early-mid stage career level and all speakers represent ten different countries. We continue
to do outreach to underrepresented minorities.

## Key facts

- **NIH application ID:** 9985451
- **Project number:** 1R13CA250271-01
- **Recipient organization:** GORDON RESEARCH CONFERENCES
- **Principal Investigator:** Hannah L. Klein
- **Activity code:** R13 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $7,000
- **Award type:** 1
- **Project period:** 2020-02-28 → 2021-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9985451

## Citation

> US National Institutes of Health, RePORTER application 9985451, 2020 DNA Damage, Mutation and Cancer GRC/GRS (1R13CA250271-01). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9985451. Licensed CC0.

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