# Genetic access and connectional assays of mouse inhibitory cortical cell types

> **NIH NIH R34** · SALK INSTITUTE FOR BIOLOGICAL STUDIES · 2020 · $812,818

## Abstract

Project Summary
The function of the nervous system is dependent on complex interactions between networks of neurons
composed of multiple neuron types. Understanding how these networks function both in health and disease is
dependent on understanding the precise connectivity between specific neuron types and their functional
interactions in the intact brain. It is therefore apparent that, in order to have an adequate understanding of the
nervous system, it is necessary to have detailed descriptions of neuronal connectivity with the same level of
precision at which these systems operate and to selectively manipulate and measure the activity of specific cell
types in the context of the normal functioning network. The research proposed here is aimed first at revealing
the detailed connectivity of inhibitory cortical neurons by developing and using a novel monosynaptic rabies
circuit tracing strategy in which input neuron types are classified using single cell sequencing. The work will
also develop and use a novel high throughput strategy for identification of cell type specific enhancer elements.
The approach used will identify enhancers that can drive transgene expression in specific types of inhibitory
cortical neurons. Together these studies will allow the development and testing of new hypotheses about the
functional contributions of specific inhibitory cortical neuron types to perception,cognition and behavior.

## Key facts

- **NIH application ID:** 9985641
- **Project number:** 1R34NS116885-01
- **Recipient organization:** SALK INSTITUTE FOR BIOLOGICAL STUDIES
- **Principal Investigator:** EDWARD M CALLAWAY
- **Activity code:** R34 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $812,818
- **Award type:** 1
- **Project period:** 2020-04-15 → 2022-09-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9985641

## Citation

> US National Institutes of Health, RePORTER application 9985641, Genetic access and connectional assays of mouse inhibitory cortical cell types (1R34NS116885-01). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9985641. Licensed CC0.

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