# Cerebrovascular resistance in cognitive aging and Alzheimer's disease risk

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA-IRVINE · 2020 · $449,769

## Abstract

Project Summary
The proposed study will investigate the role of cerebrovascular dysfunction during the earliest stages of
neurocognitive decline, prior to any obvious changes in cognition. Specifically, we will study whether
cognitively normal older adults at risk for Alzheimer's disease show increased cerebrovascular resistance. We
will also study how increased cerebrovascular resistance relates to brain dysfunction using functional brain
scans. Finally, we will investigate whether higher cerebrovascular resistance in cognitively normal older adults
predicts development of subtle cognitive decline over a two year follow-up interval.

## Key facts

- **NIH application ID:** 9985686
- **Project number:** 5R01AG060049-03
- **Recipient organization:** UNIVERSITY OF CALIFORNIA-IRVINE
- **Principal Investigator:** Daniel A Nation
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $449,769
- **Award type:** 5
- **Project period:** 2019-08-01 → 2024-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9985686

## Citation

> US National Institutes of Health, RePORTER application 9985686, Cerebrovascular resistance in cognitive aging and Alzheimer's disease risk (5R01AG060049-03). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9985686. Licensed CC0.

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