# Mentoring Investigators on the Clinical Translation of Genetic Discoveries in Type 2 Diabetes

> **NIH NIH K24** · MASSACHUSETTS GENERAL HOSPITAL · 2020 · $162,399

## Abstract

ABSTRACT
 We are entering a new era in which the explosion of genomic and biological information
across multiple developmental and metabolic states is poised to transform the practice of
medicine. The clinician's ability to absorb, assimilate and translate this information will
determine the extent of its impact on public health. There is an urgent need to train clinical and
non-clinical scientists who are competent on big biological data, and who can curate,
disseminate and implement the clinically actionable findings that emerge from ongoing efforts.
The PI on this application has dedicated himself to advance genomic and metabolomic
discoveries in type 2 diabetes, and now seeks to mentor a cadre of highly trained investigators
who will be enabled and empowered to lead the application of genomic and systems-wide
approaches to the clinical setting. To achieve this goal, he will 1) establish an infrastructure of
pertinent genomic and physiologic datasets available for mining, 2) develop a rigorous yet
nurturing training pipeline of carefully selected mentees, and 3) guide the investigation of
clinically relevant hypotheses that can be tested in the appropriate environment. Dr. Florez is
embedded in a successful and productive milieu that embraces a culture of collaboration. As the
Chief of the Diabetes Unit and member of the Center for Human Genetic Research at the
Massachusetts General Hospital, an Associate Professor at Harvard Medical School, and an
Institute Member at the Broad Institute, he is placed in a unique position that will enable him and
his trainees to benefit from direct access to an unparalleled suite of training resources and
datasets germane to the proposed patient-oriented research in type 2 diabetes and its
complications.

## Key facts

- **NIH application ID:** 9985807
- **Project number:** 5K24DK110550-05
- **Recipient organization:** MASSACHUSETTS GENERAL HOSPITAL
- **Principal Investigator:** JOSE CARLOS FLOREZ
- **Activity code:** K24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $162,399
- **Award type:** 5
- **Project period:** 2016-09-01 → 2021-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9985807

## Citation

> US National Institutes of Health, RePORTER application 9985807, Mentoring Investigators on the Clinical Translation of Genetic Discoveries in Type 2 Diabetes (5K24DK110550-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9985807. Licensed CC0.

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