# Developing the Next Generation of SWIR Fluorescent Probes

> **NIH NIH P41** · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · 2020 · $279,377

## Abstract

TRD 4: Next-generation nanoprobe toolkit for biomedical applications
Investigators: Moungi Bawendi (MIT) (4.1), Ishan Barman (JHU) (4.2), Conor Evans (MGH) (4.2,4.3), Gabriela
Schlau-Cohen (MIT) (4.3)
Collaborative Projects: Rakesh Jain (MGH) (CP1), Saraswati Sukumar, Johns Hopkins (CP10); PnP
Research Corporation(CP7), Matthew Coleman, UC Davis (CP9).
This TRD adds a synergistic focus on the development of novel molecular probes to complement and enhance
the strong spectroscopy, imaging hardware and label-free assay developments of the LBRC. Molecular probes,
tailored to our hardware development projects provide powerful toolkits that meet the demands of our
collaborators for ultrasensitive, gene- and protein-specific analysis. We seek to develop nanostructured probes
that enable new modes of visualization of biological function in real time. We are pulled by our collaborators to
develop engineered nanoprobes to study metastasis and treatment response (Jain, CP1), to understand
epigenetics factors (Sukumar, CP10), and to optimize cancer therapeutics (Coleman, CP9; PnP Research
Corporation, CP7). We will leverage our bright nanoparticles (NPs) in combination with our advances in the
other TRDs to improve our understanding, diagnosis, and monitoring of critical pathological conditions.
Ultimately, conjugation of these nanoprobes to targeting entities will enable facile detection of numerous
orthogonal biological processes.

## Key facts

- **NIH application ID:** 9985832
- **Project number:** 5P41EB015871-34
- **Recipient organization:** MASSACHUSETTS INSTITUTE OF TECHNOLOGY
- **Principal Investigator:** Peter T. So
- **Activity code:** P41 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $279,377
- **Award type:** 5
- **Project period:** 1997-06-01 → 2022-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9985832

## Citation

> US National Institutes of Health, RePORTER application 9985832, Developing the Next Generation of SWIR Fluorescent Probes (5P41EB015871-34). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9985832. Licensed CC0.

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