# Partnership Core

> **NIH NIH P01** · UNIVERSITY OF WASHINGTON · 2020 · $323,616

## Abstract

ABSTRACT – Partnership Core
The Partnership Core will provide resources and support for partnership activities essential to the execution of
the proposed research. The proposed Research Program builds on the foundational work of the Northwest-
Alaska Pharmacogenomic Research Network (NWAP), a Center within the NIGMS Pharmacogenomic
Research Network. NWAP has worked in 3 tribal settings in Alaska and Montana to conduct a range of
research studies related to pharmacogenomics, providing the basis for the present proposal, in which studies
of gene-environment-drug (GED) interactions and polygenic-drug interactions (PGD) related to anti-coagulant
and anti-platelet therapy will provide knowledge for improving the health care of American Indian and Alaska
Native (AI/AN) people, and will inform model investigational approaches. NWAP research procedures have
been accomplished through respectful university-community partnerships, guided by the values and
procedures of community-based participatory research (CBPR). The Partnership Core will assure the CBPR
functions essential to the maintenance and continued growth of the strong partnerships established in this
research consortium. These include procedures to assure tribal oversight of research procedures and
convening of groups for collaborative discussion of issues arising in the research. We have identified three
priority objectives for Partnership Core deliberation: (1) Bi-directional capacity development, assuring
appropriate training and orientation for university-based investigators with little experience in tribal research
partnerships, in particular graduate students and post-doctoral fellows involved in laboratory-based
components of our studies, and parallel training and orientation about biomedical research for community-
based partners; (2) Return of research results, developing appropriate procedures for the return of research
results at each site, in anticipation of clinically relevant findings; and, (3) Data sharing, exploring collaboratively
the development of data-sharing mechanisms that will accomplish the goals of NIH policy while retaining tribal
oversight and control of data. These activities will support the Core goals of sustaining and growing existing
community groups and collaborative procedures and assuring collaborative effort in the implementation of
Projects 1, 2 and 3, including the development of appropriate strategies to assure responsible research
practice.

## Key facts

- **NIH application ID:** 9985861
- **Project number:** 5P01GM116691-05
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **Principal Investigator:** WYLIE G. BURKE
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $323,616
- **Award type:** 5
- **Project period:** 2016-08-01 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9985861

## Citation

> US National Institutes of Health, RePORTER application 9985861, Partnership Core (5P01GM116691-05). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/9985861. Licensed CC0.

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