# PROMOTING RESEARCH CAREERS AMONG UNDERREPRESENTED MINORITY PHYSICIANS

> **NIH NIH R01** · WASHINGTON UNIVERSITY · 2020 · $433,125

## Abstract

Project Summary
Physician-scientists (MD-PhDs and other MDs) are uniquely positioned to address national healthcare
challenges by combining their clinical perspectives with scientific insight to provide a scientifically rigorous
approach to patient care. A diverse biomedical-research workforce is expected to yield a broader spectrum of
novel research questions for studying disease risk, pathogenesis and outcomes, response to treatments, and
ways to reduce health disparities. However, the physician-scientist workforce remains relatively lacking in
racial/ethnic and gender diversity compared to U.S. medical-school graduates. The objective of this project (a
second competitive renewal of R01 GM085350) is to identify barriers to and facilitators of research grant
applications, resubmissions, and awards among underrepresented groups in the federally funded biomedical-
research workforce, including racial/ethnic minority groups (e.g., Black, American Indian/Alaska Native, and
Hispanic) and women. Using a database for an entire pre-applicant population of the 1993-2000 national
cohort of 129,867 U.S. medical-school matriculants, we address six Aims, examining outcomes in relation to
demographic, institutional, research-related, educational/academic, and professional-development variables.
Aims 1-4 will identify variables associated with:1) MD-PhD-degree program enrollees' application for and
receipt of F30 and F31 pre-doctoral fellowships; 2) medical graduates' application for F32, mentored-K
(K01/K08/K23), and R01 grants; 3) applicants' receipt of F32, mentored-K and R01 awards; and 4) re-
submission of unfunded applications and subsequent awards. For racial/ethnic and gender disparities in grant
application, resubmission, and award outcomes identified in Aims 2-4, Aim 5 will identify causal mechanisms
between each of race/ethnicity and gender and each of the outcomes using causal mediation analysis. Aim 6
will identify variables associated with academic-medicine faculty promotion to a senior rank (associate
professor or full professor), attrition without promotion, and mean time to event. We will create a unique,
longitudinal database of de-identified data for individuals in this national cohort, with new data from the
Association of American Medical Colleges, American Medical Association, and the National Institutes of Health
Information for Management, Planning, Analysis, and Coordination (IMPAC) II grants database, which has
never before been linked to data for an entire national pre-applicant population. We use multivariable logistic
regression models to identify variables associated with grant outcomes, and causal mediation analysis to
identify causal mechanisms between race/ethnicity and each grant outcome. Subdistribution hazard ratios will
measure effects of variables on the instantaneous probability of two competing events, promotion and attrition;
subdistribution hazard function is directly linked to the probabilities of these competing even...

## Key facts

- **NIH application ID:** 9985865
- **Project number:** 5R01GM085350-10
- **Recipient organization:** WASHINGTON UNIVERSITY
- **Principal Investigator:** DONNA B JEFFE
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $433,125
- **Award type:** 5
- **Project period:** 2008-08-01 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9985865

## Citation

> US National Institutes of Health, RePORTER application 9985865, PROMOTING RESEARCH CAREERS AMONG UNDERREPRESENTED MINORITY PHYSICIANS (5R01GM085350-10). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9985865. Licensed CC0.

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