# Multiscale investigation of the impact of 2D confinement on adhesion protein function

> **NIH NIH R01** · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · 2020 · $278,051

## Abstract

This program addresses the grand challenge of investigating how proteins function
within the constrained two-dimensional microenvironments of adhesive contacts
between cell membranes. We propose to develop a multiscale computational and
experimental framework that predicts both molecular scale protein dynamics at
intermembrane contacts and ensemble average intermembrane binding kinetics. The
results will have broad impact for investigations of adhesion proteins within complex
microenvironments that have, until now, been largely inaccessible.

## Key facts

- **NIH application ID:** 9985866
- **Project number:** 5R01GM117104-04
- **Recipient organization:** UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
- **Principal Investigator:** Deborah E Leckband
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $278,051
- **Award type:** 5
- **Project period:** 2017-09-30 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9985866

## Citation

> US National Institutes of Health, RePORTER application 9985866, Multiscale investigation of the impact of 2D confinement on adhesion protein function (5R01GM117104-04). Retrieved via AI Analytics 2026-05-30 from https://api.ai-analytics.org/grant/nih/9985866. Licensed CC0.

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