# MS CEPR  Administrative Core

> **NIH NIH P20** · UNIVERSITY OF MISSISSIPPI MED CTR · 2020 · $499,165

## Abstract

MISSISSIPPI CENTER OF EXCELLENCE IN PERINATAL RESEARCH
ADMINISTRATIVE, MENTORING AND EDUCATION CORE A
SUMMARY
 The major goal of the Mississippi Center of Excellence in Perinatal Research (CEPR) is to develop an
innovative, independent and sustainable center of excellence in perinatal research and treatment spanning the
spectrum from adverse pregnancy to subsequent outcomes in offspring. More specifically, perinatal research
encompasses the study of disease states that may occur during gestation and early post-natal development
that result in long term consequences in the mother and offspring across their lifespan. Studies will focus on
the integrative relationships and health disparities in adverse pregnancy, pregnancy outcomes and
developmental programming of cardiovascular, renal, metabolic and behavioral diseases. This is an
important area for research especially in light of the increasing evidence of long term health consequences
brought about by adverse fetal environment and subsequent low birth weight during pregnancy both for the
mother and offspring. An adverse perinatal environment is thought to account at least in part for the
development of obesity, cardiovascular, renal, and behavioral diseases later in life for the offspring, and
predispose the mothers for increased risk of these diseases with aging. Mississippi has one of the highest
rates of preeclampsia, obesity, cardiovascular, renal and metabolic diseases and hypertension in the United
States, leading to disproportionate levels of morbidity and mortality in our population. The incidence of
preeclampsia is 10% in Mississippi, compared to 5% in the US. The prevalence of children with low birth
weight in Mississippi is 12% in Caucasian children and 18% in African American children, compared to 5-8%
in the other states. Studies that will provide novel insight into mechanisms responsible for the high rates of
these diseases in Mississippi will require a paradigm shift in research that incorporates multidisciplinary
integrated approaches, combining the efforts of basic, clinical and population scientists. A major goal of this
proposal is to develop a research Center that will provide infrastructure and capacity for a multidisciplinary,
diverse group of basic, clinical and population scientists working on the common synergistic theme of perinatal
diseases and health disparities and to facilitate their collaborations.
The specific aims of the Administrative, Mentoring and Education Core A include the following:
1. To provide overall leadership for development of infrastructure, mentoring programs and research core
facilities that foster excellence in perinatal research spanning the spectrum from adverse pregnancy to
subsequent outcomes in offspring and will lead to development of an innovative, internationally recognized
Center of Excellence.
2. To develop, implement and monitor a Mentoring and Education Program that facilitates development of
junior faculty investigators into independ...

## Key facts

- **NIH application ID:** 9985902
- **Project number:** 5P20GM121334-04
- **Recipient organization:** UNIVERSITY OF MISSISSIPPI MED CTR
- **Principal Investigator:** Jane F Reckelhoff
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $499,165
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9985902

## Citation

> US National Institutes of Health, RePORTER application 9985902, MS CEPR  Administrative Core (5P20GM121334-04). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9985902. Licensed CC0.

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