# Rapid‐Response Macromolecular Crystallography

> **NIH NIH P30** · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · 2020 · $357,385

## Abstract

Project Summary/Abstract – Technology Operations Core 1 (TOC1)
The goal of the proposed ALS-ENABLE resource is to provide an integrated and state-of-the-art structural
biology resource for NIH investigators across the country. TOC1 in particular brings together the eight ALS
macromolecular crystallography (MX) synchrotron beamlines into one national resource, creating a unified
program which extends the individual beamline strengths to the entire resource, while providing a single
interface to meet the user community needs for beamtime, data collection and data processing. The ALS
structural biology beamlines are state-of-the-art "mature" resources, collectively serving hundreds of users
annually, with dedicated beamline scientists with strong long-term collaborations with NIH-funded PIs across
the country. The three aims in TOC1 link the current automation technologies developed at the eight resource
beamlines into one complete automation pipeline, extend remote access crystallography to all the resource
beamlines, and formalize and unify the current collaborative crystallography efforts into one program. The ALS-
ENABLE resource brings together for the first time the four independent MX groups at the ALS, their eight
endstations, and the Collaborative Crystallography program into one national resource. This integration of
structural biology synchrotron beamlines at the ALS allows significant synergies and efficiencies. It builds on
the current success of the structural biology beamlines, enabling structural biology solutions on the most
challenging and relevant biological problems, thus serving the needs of the national biomedical research
community.

## Key facts

- **NIH application ID:** 9985913
- **Project number:** 5P30GM124169-04
- **Recipient organization:** UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB
- **Principal Investigator:** CORIE Y RALSTON
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $357,385
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9985913

## Citation

> US National Institutes of Health, RePORTER application 9985913, Rapid‐Response Macromolecular Crystallography (5P30GM124169-04). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9985913. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*