# eMERGE IV Northwest: A partnership to evaluate the use of genomic information in the health care of diverse participants

> **NIH NIH U01** · UNIVERSITY OF WASHINGTON · 2020 · $1,346,291

## Abstract

Project Abstract
eMERGE IV (E4) proposes to investigate the implementation of 15 “genomic risk assessment” (GRA) scores in
a network-wide set of diverse participants. These GRAs will include polygenic risk score (PRS) information, as
well as risk information, such as personal and family health history, environmental and social health
determinants, and physical and lab measures. The GRA will aggregate these factors into a single score to
identify those who would benefit from screening and other interventions.
Substantial challenges must be addressed before genomic medicine is a part of standard medical care. We will
collaborate to refine multi-ancestry GRAs and support the inclusion of non-genetic risk factors extracted from
the electronic health record with innovative natural language processing approaches and apply them in a
cohort enriched for Asian ancestry, and sexual and gender minorities. The specific aims of our proposal are
designed to use an implementation science approach to advance the integration of genomic data into clinical
practice, including evaluation of patient perspectives and economic outcomes, and broadening the impact of
eMERGE through collaborations. The University of Washington Medicine dedication to preventative health in a
learning health system and broad expertise across genomics, statistical, ethical, informatic, implementation,
outcomes and economic disciplines will support this multi-site clinical trial.
Specific Aims:
Aim 1: Refine GRA scores and outcomes measures for five high impact conditions, considering stakeholder
input, for implementation in the electronic health record. The conditions are: colorectal cancer, breast cancer,
osteoporosis, coronary artery disease, and glaucoma.
Aim 2: Integrate 15 GRA scores and electronic clinical decision support for management into clinical care and
the EHR and capture clinical outcomes.
Aim 3: Evaluate the implementation, effectiveness, and economic utility of GRA result return.

## Key facts

- **NIH application ID:** 9986310
- **Project number:** 2U01HG008657-06
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **Principal Investigator:** David Russell Crosslin
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $1,346,291
- **Award type:** 2
- **Project period:** 2015-09-01 → 2025-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9986310

## Citation

> US National Institutes of Health, RePORTER application 9986310, eMERGE IV Northwest: A partnership to evaluate the use of genomic information in the health care of diverse participants (2U01HG008657-06). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9986310. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*