# Kidney Therapeutics: Translating Discoveries into Prevention, Treatment and Cures for Kidney Diseases

> **NIH NIH P30** · NORTHWESTERN UNIVERSITY · 2020 · $1,145,719

## Abstract

PROJECT SUMMARY TO OVERALL COMPONENT
Despite recent discoveries that explain the molecular pathogenesis of a number of kidney diseases, new
therapies have been slow to emerge. With a staggering 30 million Americans suffering from kidney diseases,
there is an urgent unmet need to facilitate development of new treatments. The overall theme of the proposed
Northwestern George M. O’Brien Kidney Core Center named NU-GoKIDNEY, will focus on Kidney
Therapeutics – to translate discoveries into prevention, treatment and cures. To realize this objective, requires
extensive and productive collaborations between multiple scientific and clinical disciplines that do not
traditionally interact. Our Center will unite investigators across three Cores: the Pre-Clinical Models Core
(Core A), the Therapeutics Development Core (Core B) and the Clinical and Translational Core (Core
C). The Center will nucleate unique, unparalleled talent available at Northwestern University to accomplish this
goal, including: 1) an exceptional group of interdisciplinary kidney researchers; 2) large collection of relevant
animal models and cell lines; 3) a world-leading nanomedicine institute; 4) an innovative and world-class
chemistry department devoted to drug discovery; 5) world-leading bio-electronics expertise; 6) a renowned
team of experts in pharmacogenomics and pharmacology; 7) a high level Good Manufacturing Practices
(GMP) production facility developed by one of the core directors; 8) an electronic data warehouse comprising
6.7M individual patients linked to genomic data; 9) large biorepository of renal specimens; 10) expertise and
infrastructure to conduct first-in-human studies; 11) track record of community engagement in the conduct of
research and 12) an Innovation and New Ventures office (INVO). In addition to the establishment of the three
biomedical cores, the NU-GoKIDNEY Center will support innovative Enrichment programs and Pilot and
Feasibility studies designed to enhance cross-disciplinary collaborations, attract new investigators into the
kidney diseases field and train the next generation of kidney innovators. An online portal nephro-HUB will
provide access to these unique NU resources - for the first time - to the outside world and a Kidney Cure
Accelerator will be launched to promote therapeutic innovation and catalyse translation within Northwestern
and across the Chicagoland, national and international kidney communities.

## Key facts

- **NIH application ID:** 9986456
- **Project number:** 5P30DK114857-03
- **Recipient organization:** NORTHWESTERN UNIVERSITY
- **Principal Investigator:** Alfred L. George
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $1,145,719
- **Award type:** 5
- **Project period:** 2018-08-01 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9986456

## Citation

> US National Institutes of Health, RePORTER application 9986456, Kidney Therapeutics: Translating Discoveries into Prevention, Treatment and Cures for Kidney Diseases (5P30DK114857-03). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/9986456. Licensed CC0.

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