# Functional Genomics Core

> **NIH NIH P30** · CINCINNATI CHILDRENS HOSP MED CTR · 2020 · $105,986

## Abstract

The Functional Genomics Core (FGC) will provide reagents, strategic, and technical expertise required for
efficient investigation of genetic variants likely to be mechanistically important in pediatric rheumatic and
inflammatory diseases. In doing so, the FGC will enhance research productivity and efficiency by effectively
reducing the “start-up” time required to implement these complex experimental systems, thus reducing costs
and effort required and allowing for better study designs and higher quality studies than if investigators were to
individually establish this technology. Further, this core will provide access to state-of-the-art technology
without requiring the users to become experts in these technologies. The FGC core will be a practical vehicle
for the translation of basic advances to clinical disease applications and their very important insights in to
pathogenesis. We will specifically provide consultation, collaboration, hands-on technical expertise and starter
reagents to the research community to identify the biological function of genetic variants (Aim1) and apply
genomic editing technology (Aim 2) to assess the biological function of genetic variants associated with of
autoimmune, autoinflammatory, and immune-related rheumatic pediatric diseases. We expect the FGC to be a
hub of innovation for the research community, connecting scientists with the tools and expertise to take their
research projects to the next level and to accelerate the discovery of the molecular mechanisms that are
responsible for the genetic associations observed.

## Key facts

- **NIH application ID:** 9986692
- **Project number:** 5P30AR070549-05
- **Recipient organization:** CINCINNATI CHILDRENS HOSP MED CTR
- **Principal Investigator:** John Barker Harley
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $105,986
- **Award type:** 5
- **Project period:** 2016-08-01 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9986692

## Citation

> US National Institutes of Health, RePORTER application 9986692, Functional Genomics Core (5P30AR070549-05). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/9986692. Licensed CC0.

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