# Data, Modeling,and Coordination Center for PrecISE Network

> **NIH NIH U24** · UNIV OF NORTH CAROLINA CHAPEL HILL · 2020 · $13,299,576

## Abstract

ABSTRACT
The goal of this U24 application is to establish the Data, Modeling, and Coordination Center (DMCC) for the
NHLBI's Precision Interventions for Severe and/or Exacerbation-Prone Asthma (PrecISE) Network. The
objective of PrecISE is to conduct sequential, adaptive, phase II/proof of concept trials with precision
interventions in stratified patient with severe asthma populations. Patients with severe asthma are
heterogeneous, and thus a hard to treat population. Precision medicine interventions, which focus on
identifying the best treatments for individual patients instead of the best treatments for the most patients, could
improve overall outcomes among this complex patient population. The PrecISE Network is poised to address
these issues. Central to its success will be an innovative, forward-looking, and productive Coordinating Center
that brings cohesion to the participating Clinical Center investigators by sharing their visions and providing
scientific leadership, organizational support and analytic results for PrecISE trials. Key elements that will
enhance collaboration and research progress include experienced leadership, innovative design and analysis
methodologies (e.g., sequential adaptive designs, machine learning, neural networks, Q-learning),
comprehensive research operations support, a state-of-the-art data management system, and superior
administrative support. Our infrastructure will provide both public and private websites which include PrecISE
information pages for the public, participants, and investigators, frequently asked questions, study materials,
project calendar, a communications hub, and other key features. We will develop a secure, user-friendly
advanced data management system that includes web-based access for surveys, data entry, research
management (including comprehensive reporting, biosample tracking and performance-based reimbursement
tools), integration with external applications, and quality control. Our research operations and administration
teams will provide a solid foundation to PrecISE by facilitating communication including meeting arrangements
and minutes, collaborative document preparation, tracking of regulatory compliance, and support for abstract
and publication preparation across the PrecISE Network. Together, this integrated structure will set the stage
for the execution of high-impact, sequential, adaptive, phase II/proof of concept trials in the PrecISE Network,
which can lead to the establishment of potential personalized treatment approaches for patients with severe
and/or exacerbation-prone asthma.

## Key facts

- **NIH application ID:** 9986880
- **Project number:** 5U24HL138998-04
- **Recipient organization:** UNIV OF NORTH CAROLINA CHAPEL HILL
- **Principal Investigator:** ANASTASIA IVANOVA
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $13,299,576
- **Award type:** 5
- **Project period:** 2017-09-23 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9986880

## Citation

> US National Institutes of Health, RePORTER application 9986880, Data, Modeling,and Coordination Center for PrecISE Network (5U24HL138998-04). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9986880. Licensed CC0.

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