# Core 5: Biostatistics and Bioinformatics

> **NIH NIH P01** · DANA-FARBER CANCER INST · 2020 · $165,964

## Abstract

Project Summary (Core 5)
Studies from the previous grant period confirmed that achieving MRD negative (sensitivity of 1 cell in 10-6)
status provides significantly superior progression free and overall survival outcome. In this proposal, we will
address the question of how MRD status will inform the therapeutic approach in a randomized phase III study
comparing two maintenance schedules for MRD negative patients. To support this effort, the Bioinformatics
and Biostatistics Core E will provide 1) support and direction on the formatting, quality control and annotation
procedures of clinical and research data as well as the process of transferring the research data a data
warehouse for integrative analysis, 2) bioinformatics support for primary and integrative analysis of the high-
throughput data and 3) biostatistics support in terms of design and analysis for all projects. Core members will
work closely with project members as well as Cores 1 and 2 with regard to quality control, specimen tracking
and data transfer procedures as well as Cores 3 and 4 which will perform microarray based gene and miRNA
expression profiling, and SNP genotyping and next generation sequencing for identifying genomic and
transcriptomic changes. Bioinformatics and biostatistics support and analysis is not only required for individual
projects, but it is crucial for the integrative analysis from data across the projects and thus overall success of
the program.

## Key facts

- **NIH application ID:** 9987294
- **Project number:** 5P01CA155258-09
- **Recipient organization:** DANA-FARBER CANCER INST
- **Principal Investigator:** Giovanni Luigi PARMIGIANI
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $165,964
- **Award type:** 5
- **Project period:** 2011-12-01 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9987294

## Citation

> US National Institutes of Health, RePORTER application 9987294, Core 5: Biostatistics and Bioinformatics (5P01CA155258-09). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/9987294. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*