# Immunopathology Core

> **NIH NIH P01** · MASSACHUSETTS GENERAL HOSPITAL · 2020 · $172,709

## Abstract

CORE SUMMARY / ABSTRACT
The Immunopathology Core is a central resource for all three projects in the PPG. The Specific Aims are to
provide: 1) expert pathological and immunopathological interpretation of the allograft in each of the three
projects, which is critical in the evaluation of tolerance or rejection; 2) innovative staining methods directed at
answering the specific scientific questions that arise in each of the projects as requested by the investigators;
3) high quality, uniform histochemical/immunohistochemical preparations common to all projects. 4) advice on
the design of experiments to optimize the potential pathological studies; 5) ready investigator access to
scanned images and digital photographs for publication; and 6) common and advanced computer analysis for
morphometrics and 3-D reconstruction. Each project will use the Core to determine the status of the allograft
along the axis of tolerance--rejection, and the specific features of either (e.g., are there intragraft Treg-rich
organized lymphoid structures (TOLS) or is the graft free of infiltrate; is the rejection antibody or T cell
mediated?). The techniques to be provided include: standard scoring of allograft samples (Banff, ISHLT and
custom schema), immunohistochemistry and immunofluorescence for cell identification and status, whole slide
digital imaging and morphometrics for quantitation of infiltrates and vascular lesions. Each project will use the
Core to determine the status of the allograft along the axis of tolerance--rejection, and the specific intragraft
features of either. The results from the Core analysis will be essential to assess the success and mechanisms
of the protocols.

## Key facts

- **NIH application ID:** 9987471
- **Project number:** 5P01AI123086-05
- **Recipient organization:** MASSACHUSETTS GENERAL HOSPITAL
- **Principal Investigator:** Robert B Colvin
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $172,709
- **Award type:** 5
- **Project period:** 2016-08-05 → 2022-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9987471

## Citation

> US National Institutes of Health, RePORTER application 9987471, Immunopathology Core (5P01AI123086-05). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/9987471. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*