# BCM-Rice resource for the analysis of somatic gene editing in mice

> **NIH NIH U42** · BAYLOR COLLEGE OF MEDICINE · 2020 · $695,141

## Abstract

Project Summary – Overall
Genome editing systems have the potential to cure some of the most severe human diseases. However, there
are significant challenges that must be addressed before this technology can be applied in clinical trials including
identification of appropriate delivery systems for specific tissues, evaluation of overall efficiency and specificity
of delivery and genome editing systems, and assessment of efficacy and safety of both delivery and genome
editing technologies. The BCM-Rice Resource Center for the Analysis of Somatic Gene Editing in Mice will
create mouse model resources for in vivo testing of somatic genome editing tools developed by members of the
Somatic Cell Genome Editing (SCGE) program, will assist researchers within the program with evaluation of
genome editing strategies using these new models, and will deposit genome editing reporter mouse strains into
a publically accessible repository for distribution to the wider scientific community. Our long term goal is to
accelerate the clinical development of somatic genome editing for human disease by defining the benefits and
risks of novel Delivery Technologies and Editing Systems. The Overall section provides a statement of
significance, a synopsis of the work to be performed, relevant descriptions of the resources available for this
project at BCM and Rice, a description of the qualifications of the PIs and research team and a description of
previous expertise and infrastructure relevant to this proposal. Together, these sections convey the strengths of
BCM-Rice as a proposed site for a new Resource Center for the Analysis of Somatic Gene Editing. It is clear
that the Texas Medical Center (TMC) community will bring significant benefits to the project and this project will
also strongly benefit the TMC community.

## Key facts

- **NIH application ID:** 9987750
- **Project number:** 5U42OD026645-03
- **Recipient organization:** BAYLOR COLLEGE OF MEDICINE
- **Principal Investigator:** Mary E Dickinson
- **Activity code:** U42 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $695,141
- **Award type:** 5
- **Project period:** 2018-09-18 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9987750

## Citation

> US National Institutes of Health, RePORTER application 9987750, BCM-Rice resource for the analysis of somatic gene editing in mice (5U42OD026645-03). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9987750. Licensed CC0.

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