# Computational/Biostatistical Core

> **NIH NIH P50** · WEILL MEDICAL COLL OF CORNELL UNIV · 2020 · $219,767

## Abstract

COMPUTATIONAL BIOLOGY AND BIOSTATISTICS CORE SUMMARY
The Computational Biology and Biostatistics Core (CBBC) will provide essential computational and
biostatistical services and resources for all projects of the WCM SPORE in Prostate Cancer (PCa). Analytic
services include statistical design and analysis, extensive quality control, integrative analysis and interpretation
of genomic (DNA-seq, RNA-seq) epigenomic (ChIP-seq, bisulfite sequencing) datasets and implementation
and development of custom computational pipelines needed by the projects. Core investigators include Drs
Elemento and Ballman (Co-Directors), Dr Sboner (Co-investigator) and Dr Demichelis (Co-investigator). All
CBBC investigators are highly experienced scientists with an extensive track record of publications and grants
in their field and have authored first, last or co-author publications in prostate cancer. CBBC investigators have
developed key computational biology methods ranging from pathway and motif analysis (iPAGE and FIRE) to
fusion detection (FusionSeq) and tumor and mutational clonality analysis (CLONET). In addition to analytic
services, the Computational Biology and Biostatistics Core will provide centralized access to a number of
computational tools developed by the core investigators as well as direct access to expertise for the design
and analysis of genomic and epigenomic experiments. The Computational Biology and Biostatistics Core will
take advantage of the shared computational infrastructure of the Institute for Computational Biomedicine (ICB)
at Weill Cornell Medicine (WCM) and of clinical-grade computational pipelines already developed in the context
of the WCM/NewYork-Presbyterian Hospital (NYPH) Englander Institute for Precision Medicine (IPM).
Specifically, CBBC will provide computational analysis of genomic, epigenomic, and transcriptional profiling for
all Projects and Cores that are part of this SPORE (Aim 1). CBBC will also provide the full spectrum of
statistical services for all Projects and Cores that are part of the SPORE (Aim 2). Project 1 (co-led by Dr
Beltran and Demichelis), Project 2 (co-led by Drs Rickman and Beltran), Project 3 (co-led by Drs. Rubin,
Tomlins, and Shen) and Project 4 (co-led by Dr. Barbieri and Shen) will all use the CBBC. In addition, CBBC
will support DRP and CEP projects as they develop.

## Key facts

- **NIH application ID:** 9988243
- **Project number:** 5P50CA211024-04
- **Recipient organization:** WEILL MEDICAL COLL OF CORNELL UNIV
- **Principal Investigator:** Olivier Elemento
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $219,767
- **Award type:** 5
- **Project period:** 2017-08-30 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9988243

## Citation

> US National Institutes of Health, RePORTER application 9988243, Computational/Biostatistical Core (5P50CA211024-04). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/9988243. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*