K12 Career Development Program in Emergency Critical Care Research University of Michigan PD/PIs: Robert Neumar, M.D.-Ph.D.; David J. Pinsky, M.D. The goal of the proposed program is to prepare a diverse group of early career clinician-scientists for leadership roles and independent research careers in emergency critical care research through a multidisciplinary, mentored career development program focused on developing innovative approaches to severe, acute, life-threatening illness and injury in emergency settings. This career development program for advanced learning in emergency critical care research will be led by Robert W. Neumar, M.D.-Ph.D., Chair of Emergency Medicine, and David J. Pinsky, Director of the Samuel Frankel Cardiovascular Center (CVC). Scholars may choose mentoring teams led by experienced and highly published senior clinician-scientists in Emergency Medicine, Pulmonary and Critical Care, Neurology, General and Trauma Surgery, Cardiovascular Disease, Biomedical Engineering, and Biostatistics. Career development will emphasize all phases of emergency critical care research and practice in a collaborative culture emphasizing the close interdependence of excellence in direct patient care and clinical research. Commitment of faculty, across not only the breadth of the University of Michigan Health System (UMHS), but also multiple schools at UM, represents a singular strength of this program. Mentors with active NIH funding will guide Scholars in designing individual development plans and achieving milestones including academic courses, professional development training, expert consultations, and research to produce preliminary data for research project funding. Scholars will be expected to transition to individual K or R01 funding by the end of the third year of K12 support. Immediate/Long-term Objectives: 1. Recruit 4 junior faculty Scholars with diverse backgrounds and demonstrated commitment to emergency critical care clinical research and innovative approaches to screening, diagnosis, and clinical management of patients manifesting cardiovascular/neurovascular/ pulmonary/ disease, sepsis, or trauma. 2. Pair each Scholar with a multidisciplinary mentoring team committed to the Scholar's development and achievement of milestones set forth in a customized individual career development plan for three years. 3. Provide comprehensive on-the-job/on-campus clinical research career development program leading to an M.S. in Clinical Research Design and Statistical Analysis (CRDSA) offered for clinician-scientists. 4. Advance Scholars toward independent research careers through additional didactic training in clinical trial design and oversight, data safety and monitoring, data management and security, scientific writing, grant writing, technology development, scientific presentations, responsible conduct of research, and leadership. 5. Immerse each Scholar in the mentor's research program, a diverse campus network of collabora...