# BIOSTATISTICS AND BIOINFORMATICS CORE

> **NIH NIH P50** · SLOAN-KETTERING INST CAN RESEARCH · 2020 · $179,295

## Abstract

The role of the Biostatistics and Bioinformatics Core is to support the investigators of the SPORE in Lymphoma
in their research efforts, including laboratory experiments, molecular studies and the design and analysis of
clinical trials. In laboratory experiments, core members will assist in the formulation of the experimental design
and in the analysis and interpretation of the data at the conclusion of the study. In molecular studies, Core
members will closely interface with the members of the Biospecimen Repository Core, and will have primary
responsibility of merging molecular and clinical data, followed by appropriate statistical analysis and reporting.
In the clinical trial design phase, a core member will conduct a protocol review with the principal investigator.
Based on this, a statistical section for the protocol will be provided, outlining major scientific objectives,
population to be studied, primary and secondary endpoints, experimental design, a randomization procedure if
necessary, analysis plans, and a targeted sample size justified in probabilistic terms. At the conclusion of the
trial, data analyses will be performed to assess outcomes of the primary and secondary endpoints stated in the
protocol. If current statistical methodology does not adequately address a research question in this SPORE,
alternative methodologies will be explored.
Specific Aim 1: To provide statistical and bioinformatic expertise in experimental design, data analysis and
interpretation. The core will be involved in the studies from the conception stage all the way to its completion
and dissemination.
Specific Aim 2: To develop and/or adapt and implement novel statistical and bioinformatic methodologies to
meet need when standard methods are less than optimal.
Specific Aim 3: To provide informatics infrastructure to enable collaboration and data sharing among the
various projects and the three institutions that constitute this spore.

## Key facts

- **NIH application ID:** 9988852
- **Project number:** 5P50CA192937-05
- **Recipient organization:** SLOAN-KETTERING INST CAN RESEARCH
- **Principal Investigator:** VENKATRAMAN E SESHAN
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $179,295
- **Award type:** 5
- **Project period:** 2016-08-30 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9988852

## Citation

> US National Institutes of Health, RePORTER application 9988852, BIOSTATISTICS AND BIOINFORMATICS CORE (5P50CA192937-05). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/9988852. Licensed CC0.

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