# Interaction of Nucleoside Reverse Transcriptase Inhibitor Pharmacology and Aging in the Multicenter AIDS Cohort Study

> **NIH NIH R21** · UNIV OF NORTH CAROLINA CHAPEL HILL · 2020 · $230,075

## Abstract

PROJECT SUMMARY
The goal of the current study is to examine the effect of aging and systemic inflammation on the concentrations
of nucleoside reverse transcriptase inhibitor metabolites within cells, as compared to the endogenous
nucleotides they compete with to inhibit HIV viral replication. The study will be conducted using samples taken
from HIV+ men ≤45 years and ≥60 years, who are enrolled in the Multicenter AIDS Cohort Study, and were
taking tenofovir disoproxil fumarate and emtricitabine as part of their antiretroviral therapy. First, we will measure
the concentrations of the intracellular metabolites and endogenous nucleotides of tenofovir and emtricitabine in
stored PBMC samples, and compare the concentrations and ratios of metabolites to the corresponding
nucleotides between age groups. Second, we will measure select cytokines in matching plasma and conduct
multiple linear regression to ascertain the influence of age and inflammation on the metabolites measured in
PBMCs. Ultimately, by advancing our knowledge of the effect of aging on the pharmacology of these agents
within HIV+ patients, we can gain insight into how therapy may be adjusted with increasing age to increase
efficacy and decrease toxicity.

## Key facts

- **NIH application ID:** 9989006
- **Project number:** 5R21AG063660-02
- **Recipient organization:** UNIV OF NORTH CAROLINA CHAPEL HILL
- **Principal Investigator:** Julie Brumer Dumond
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $230,075
- **Award type:** 5
- **Project period:** 2019-08-15 → 2022-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9989006

## Citation

> US National Institutes of Health, RePORTER application 9989006, Interaction of Nucleoside Reverse Transcriptase Inhibitor Pharmacology and Aging in the Multicenter AIDS Cohort Study (5R21AG063660-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9989006. Licensed CC0.

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