# Immunology Core

> **NIH NIH U19** · EMORY UNIVERSITY · 2020 · $253,664

## Abstract

The Immunology Core of the TBRU is led by John Altman. With his group at the Emory Vaccine Center and 
their expertise in MHC tetramer technology, development of advanced flow cytometry methods, and 
development of novel viral vector antigen delivery systems for in vitro T cell assays, and along with the 
collaboration of Alessandro Sette's group at the La Jolla Institute of Allergy and Immunology and their 
expertise in epitope mapping, application of MHC peptide binding algorithms, and HLA typing, the 
Immunology Core of the TBRU will be able to perform the most sophisticated-to-date analyses of the 
phenotypes of T cell responses to Mycobacterium tuberculosis (Mtb) in humans (Projects 1 and 2) and 
rhesus macaques (Project 3). The activities of the Immunology Core include both provision of centralized 
standard support services and reagents, as well as development of important novel reagents and research 
activities. Standard support services include provision of MHC typing in humans and rhesus macaques; 
maintenance and distribution of peptide libraries; and construction, validation, and distribution of MHC 
tetramers, all to be used by every TBRU project. Innovative research activities include application of a viral 
antigen delivery system that will enable screening of more than 60 Mtb antigens for T cell responses in 
rhesus macaques, development of novel cell lines and MHC tetramer reagents for mapping epitopes and 
their MHC restriction elements, and application of CyTOF mass cytometry technology including the use of 
mass-tagged MHC tetramers ^to enable multiparametric descriptions of Mtb-specific T cells that will be 
tested for their use as biomarkers indicative of defined disease and infection states.

## Key facts

- **NIH application ID:** 9989026
- **Project number:** 5U19AI111211-07
- **Recipient organization:** EMORY UNIVERSITY
- **Principal Investigator:** John David Altman
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $253,664
- **Award type:** 5
- **Project period:** 2014-08-11 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9989026

## Citation

> US National Institutes of Health, RePORTER application 9989026, Immunology Core (5U19AI111211-07). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9989026. Licensed CC0.

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