# Genomics Core

> **NIH NIH P01** · RESEARCH INST OF FOX CHASE CAN CTR · 2020 · $155,052

## Abstract

PROJECT SUMMARY/ABSTRACT
The objective of this program project application is to gain insight into the molecular basis by which genome-
wide remodeling of E box DNA binding protein activity, in response to TCR signals, controls the development
and functional specialization of γδ T cells, which are critically important to host defense. In supporting this effort,
the Genomics Core would provide centralized access to scRNA-Seq, ChIP-Seq, ATAC-Seq and HiC
sequencing platforms to allow large-scale genomic location analysis of transcription factors as well as epigenetic
marks to reveal and describe the chromatin landscapes of αβ and γδ T-lineage cells. The Genomics Core would
generate robust single-cell transcriptomic and small-cell-number epigenetic datasets, epigenetic landscapes as
well as methods to describe the folding patterns of human and murine αβ and γδ T-lineage cells in global terms.
The Genomics Core would assist the participating laboratories for experimental design and work closely with
the participating members of the program to analyze individual, as well as, combined data sets. The Genomics
Core will also continue to generate new bioinformatics pipelines to process genome-wide data sets obtained
from bulk populations as well as data obtained from single cells. Finally, in addition to the provision of core
services, the Genomics Core would be a hub for the training of graduate students and postdoctoral fellows in
the utilization of deep DNA sequencing and associated bioinformatics techniques for the participating
laboratories.

## Key facts

- **NIH application ID:** 9989059
- **Project number:** 5P01AI102853-07
- **Recipient organization:** RESEARCH INST OF FOX CHASE CAN CTR
- **Principal Investigator:** CORNELIS MURRE
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $155,052
- **Award type:** 5
- **Project period:** 2014-05-15 → 2024-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9989059

## Citation

> US National Institutes of Health, RePORTER application 9989059, Genomics Core (5P01AI102853-07). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9989059. Licensed CC0.

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