# Bioinformatics, Biostatistics, and Image Analyses Core

> **NIH NIH P01** · MASSACHUSETTS GENERAL HOSPITAL · 2020 · $271,674

## Abstract

Project Summary
The goals of the Bioinformatics, Biostatistics, and Image Analyses Core are to provide biostatistical and
bioinformatics expertise and computational tools for genome-scale transcriptomic and epigenomic studies, as
well as perform multiplex immunofluorescence profiling and analyses of tumor immune microenvironments. The
work of the Core will ensure optimal study designs, quality control, and statistical analyses of data, as well as
sophisticated integration of data across different datasets and animal species. Analyses of ChIP-seq and RNA-
seq data will utilize state-of-the-art algorithms developed by a Core Co-Director. Multiplex immunofluorescence
is coupled with quantitative digital image analysis using tissue and individual cell segmentation and cell
phenotype analysis algorithms.
The specific aims of this Core are: 1) Support transcriptomic (RNA-seq) and epigenomic (ATAC-seq and ChIP-
seq) analyses of cells and tumors upon gene and/or drug perturbation. 2) Support single-cell RNA-seq and T-
cell receptor repertoire data analyses. 3) Support genetic screen data analyses and integration. 4) Conduct
multiplex immunohistochemistry profiling and analyses. 5) Integrate data on cell lines and animal models with
data from clinical samples and clinical trials. 6) Provide biostatistical and power analyses support. 7) Support
data management and sharing among the different projects
The rigorous computational tools and analyses provided by the Core will maximize confidence in validation of
results and generation of new hypotheses toward the objective of overcoming resistance to targeted and
immunotherapies for melanoma.

## Key facts

- **NIH application ID:** 9989073
- **Project number:** 5P01CA163222-07
- **Recipient organization:** MASSACHUSETTS GENERAL HOSPITAL
- **Principal Investigator:** Xiaole Shirley Liu
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $271,674
- **Award type:** 5
- **Project period:** 2013-03-12 → 2024-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9989073

## Citation

> US National Institutes of Health, RePORTER application 9989073, Bioinformatics, Biostatistics, and Image Analyses Core (5P01CA163222-07). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9989073. Licensed CC0.

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