# Ameliorating lymphocyte depletion and functional impairment following lung SBRT

> **NIH NIH R01** · UNIVERSITY OF VIRGINIA · 2020 · $204,253

## Abstract

Abstract
Objectives: To evaluate the efficacy of minimizing Stereotactic Body Radiation Therapy (SBRT)
effects on lymphocytes and improving overall survival and immune function by selectively
reducing dose to blood rich organs, and increasing the dose confomality in the thorax.
Method: This will be achieved in two steps: (A) Determine lymphocyte depletion, phenotype
and function of lymphocytes in optimized versus un-optimized plans in total of 50 patients under
a randomized pilot study. We will evaluate peripheral blood mononuclear cells collected at
baseline and at end of treatment, 4, and 24 weeks after lung SBRT on the clinical trial and
compare the data for the two arms. (B) Improve the existing simulation algorithm to predict the
total lymphocyte loss for a given Radiation Therapy (RT) beam plan using the clinical trial data.
This model will take into account patient specific (i) total blood volume (ii) initial lymphocyte
count (iii) tumor volume (iv) the organs from the Thorax CT data set (v) time dependent dose
map through each organ for a given delivery system, and plan, and convolve these with general
information from published literature such as (i) varying blood output to organs (ii) blood velocity
for all organs (iii) Random mixing of blood after each trip through the exposed dose area, with
the remaining blood volume of the body.

## Key facts

- **NIH application ID:** 9989076
- **Project number:** 5R01CA234281-02
- **Recipient organization:** UNIVERSITY OF VIRGINIA
- **Principal Investigator:** Krishni Wijesooriya
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $204,253
- **Award type:** 5
- **Project period:** 2019-09-01 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9989076

## Citation

> US National Institutes of Health, RePORTER application 9989076, Ameliorating lymphocyte depletion and functional impairment following lung SBRT (5R01CA234281-02). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/9989076. Licensed CC0.

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