# Core B: Transgenic and Gene-Targeting Institutional Facility

> **NIH NIH P30** · UNIVERSITY OF KANSAS MEDICAL CENTER · 2020 · $154,995

## Abstract

Project Summary / Abstract
The use of genetically altered mouse and stem cell models are critical tools for research members of the COBRE
Project in Molecular Regulation of Cell Development and Differentiation at the University of Kansas Medical
Center. The production and analysis of such models ultimately lead to better understanding of basic mechanisms
of differentiation and gene expression, functional genomics of disease progression, and in vivo models for
diagnostics and treatment. The Transgenic and Gene Targeting shared resource (TGIF), led by Jay L. Vivian
PhD, supports members of COBRE and researchers in the Kansas City area by providing centralized technical
services for the production of novel transgenic and gene-targeted rodents and genetically altered pluripotent
stem cells. The Facility uses cutting edge methods, state-of-the-art instrumentation, and novel reagents for the
generation of these models. The COBRE support of the TGIF allows for the development of specific initiatives
in the Facility relevant to these researchers. Recent initiatives include successful integration of emerging
technologies, including in vivo genome editing methods (e.g. CRISPR/Cas9 and TALE nucleases) to provide a
more rapid means of generating novel mouse models. The integration of these continually evolving methods
into the `toolbox' of the TGIF greatly accelerates the development of animal and stem cell models of development
and differentiation, while also reducing the overall costs to COBRE researchers.

## Key facts

- **NIH application ID:** 9989129
- **Project number:** 5P30GM122731-04
- **Recipient organization:** UNIVERSITY OF KANSAS MEDICAL CENTER
- **Principal Investigator:** JAY L VIVIAN
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $154,995
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9989129

## Citation

> US National Institutes of Health, RePORTER application 9989129, Core B: Transgenic and Gene-Targeting Institutional Facility (5P30GM122731-04). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9989129. Licensed CC0.

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