# Efferocytosis and the resolution of inflammation after intracerebral hemorrhage

> **NIH NIH R01** · YALE UNIVERSITY · 2020 · $366,406

## Abstract

Project Summary
 Intracerebral hemorrhage (ICH) is a devastating type of stroke with 40% fatality and no specific
treatment. In a murine model of ICH, the PI has demonstrated that the recruitment of blood-derived
inflammatory monocytes to the perihematomal region leads to significant injury in the first days after ICH.
However, over time, these cells contribute to phagocytosis and functional recovery. The signals that modulate
the macrophages from injurious to beneficial are unknown. The proposed work will determine the role of a
fundamental process in wound healing, the efferocytosis of apoptotic cells, in resolving inflammation in the
brain and aiding in recovery.
 Preliminary work demonstrates that the efferocytosis receptors Axl and Mer are expressed on blood-
derived macrophages in the brain after ICH. Furthermore, macrophages lacking Axl and Mer have higher pro-
inflammatory states and fail to respond to exogenous IL-4 in the context of erythrocyte exposure. The primary
hypothesis is that the engagement of Axl and Mer by apoptotic cells in the brain after ICH drives the
polarization of macrophages towards phenotypes that aid in wound healing and brain repair. The overall goal
of the proposal is to determine whether manipulation of this pathway can reduce early injury and enhance
repair after ICH.

## Key facts

- **NIH application ID:** 9989187
- **Project number:** 5R01NS095993-05
- **Recipient organization:** YALE UNIVERSITY
- **Principal Investigator:** LAUREN H SANSING
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $366,406
- **Award type:** 5
- **Project period:** 2016-09-01 → 2021-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9989187

## Citation

> US National Institutes of Health, RePORTER application 9989187, Efferocytosis and the resolution of inflammation after intracerebral hemorrhage (5R01NS095993-05). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9989187. Licensed CC0.

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