# Medicinal Chemistry Core

> **NIH NIH P01** · UNIVERSITY OF KENTUCKY · 2020 · $203,010

## Abstract

Medicinal Chemistry Core
The Medicinal Chemistry Core provides an integrated approach not only for the synthesis of small molecules,
but the assessment of their likely success as translational agents through feedback mechanisms involving
biological testing and cheminformatics analyses. The Core anticipates time commitments of 25% for Project 1,
25% for Project 2, and 50% for Project 3. Projects 1 and 2 will initially test aminoglycosides and deoxyglucose
analogs, respectively, available through collaborations with other research groups. The Core will provide
synthetic services related to these compounds as needed. Project 3 requires the development of glycogen
synthase inhibitors through a collaborative process of screening, structure analysis, synthesis and testing. The
Core will perform the following Specific Aims: [1] analyze and prioritize structures from high-throughput
screening; [2] synthesize glycogen synthase inhibitors for structure-activity relationship generation; and [3]
evaluate lead inhibitors in hERG activation, blood-brain barrier permeation, and P-glycoprotein interaction
assays.

## Key facts

- **NIH application ID:** 9989203
- **Project number:** 5P01NS097197-05
- **Recipient organization:** UNIVERSITY OF KENTUCKY
- **Principal Investigator:** DAVID STEWART WATT
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $203,010
- **Award type:** 5
- **Project period:** 2016-07-01 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9989203

## Citation

> US National Institutes of Health, RePORTER application 9989203, Medicinal Chemistry Core (5P01NS097197-05). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/9989203. Licensed CC0.

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