# Yale Center for Molecular Discovery Shared Resource

> **NIH NIH P30** · YALE UNIVERSITY · 2020 · $104,063

## Abstract

YALE CENTER OF MOLECULAR DISCOVERY
PROJECT SUMMARY/ABSTRACT
In late 2011, Yale University combined 2 successful exisiting cores, Small Molecule Discovery Center and High
Throughput Cell Biology, into a single core: Yale Center for Molecular Discovery (YCMD). YCMD was
established to provide high-throughput and high-content screening and assay development, as well as
medicinal chemistry services. YCMD works with individuals from Yale Cancer Center (YCC) and other Yale
laboratories to design, optimize, and execute all phases of small molecule and siRNA screening in customized
biochemical, cell-based, and model organism-based assays. YCMD synergizes existing technologies and
expertise and helps expand the capabilities and impact of investigators’ novel concepts by mining pathways or
identifying small molecule leads in a cost-effective manner. As a YCC shared resource, YCMD offers services
that span a range of investigator-driven goals and needs.
During the most recent funding period, 49 laboratories have used YCMD. Thirty of these users (61%) were
YCC members. This Shared Resource was most widely used by Developmental Therapeutics (DT), but nearly
all of the YCC research programs benefited from this core.
YCMD helped YCC members in basic and translational research address fundamental questions in biology. In
pursuit of translational research, YCMD scientists discover novel small molecule probes that may serve as
starting points for new therapeutics, to understand basic biological processes and to crystallize proteins in
unique conformations that reveal their mechanisms of action. Crystal structures enable structure-based drug
design to inform hypotheses for development of new molecules with increased binding, solubility, or
attachment of linker groups.
The Specific Aims of YCMD are to: (1) Facilitate new lines of research for YCC members and other Yale
faculty; (2) Support early-stage development for translational research programs; and (3) Make the YCMD
suite of technologies required for assay development and high-throughput screening accessible to a wide user
base.

## Key facts

- **NIH application ID:** 9989593
- **Project number:** 5P30CA016359-41
- **Recipient organization:** YALE UNIVERSITY
- **Principal Investigator:** CRAIG M CREWS
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $104,063
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9989593

## Citation

> US National Institutes of Health, RePORTER application 9989593, Yale Center for Molecular Discovery Shared Resource (5P30CA016359-41). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9989593. Licensed CC0.

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