# Viral dynamics of rebound and control following early treatment of HIV/SIV

> **NIH NIH P01** · BETH ISRAEL DEACONESS MEDICAL CENTER · 2020 · $1,516,899

## Abstract

ABSTRACT
The striking identification of select patients who were able to durably control HIV rebound after ART
discontinuation in the ANRS Visconti cohort, or in cases such as the Mississippi baby, have highlighted the
possibility of sustained HIV remission and provided the first proof of concept that HIV remission may be
clinically achievable. In several of these cases, post-treatment control is characterized by the very low, but
detectable presence of HIV infected cells implying that in at least some cases of viral remission, a balance may
have been struck between HIV-1 and the host.
The mechanism(s) by which these reservoirs are subject to sustained virologic remission or ultimately rebound,
upon ART interruption is not understood. Moreover, there is no validated biomarker that can predict
clinical outcome during a treatment interruption. Therefore, a detailed understanding of the factors that
dictate HIV suppression or relapse, in the absence of antiretroviral therapy, is critical to develop approaches to
therapeutically foster HIV-1 remission in ART-treated patients.
Thus, we propose detailed studies to define the impact of early antiretroviral therapy on virologic and
immunologic outcomes that are relevant to achieving HIV remission and durable virus control after the
cessation of ART. These studies encompass multi-disciplinary collaborations, to have the greatest breadth of
investigation, and ultimately the greatest scientific impact. Our proposed investigations include analytic
studies in both HIV-infected adult and pediatric patients. We will also conduct parallel studies in non-
human primates, including the pre-clinical evaluation of novel eradication therapeutics.

## Key facts

- **NIH application ID:** 9989762
- **Project number:** 5P01AI131365-04
- **Recipient organization:** BETH ISRAEL DEACONESS MEDICAL CENTER
- **Principal Investigator:** James Burton Whitney
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $1,516,899
- **Award type:** 5
- **Project period:** 2017-08-11 → 2021-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9989762

## Citation

> US National Institutes of Health, RePORTER application 9989762, Viral dynamics of rebound and control following early treatment of HIV/SIV (5P01AI131365-04). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9989762. Licensed CC0.

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