# Using single-cell approaches to study inflammatory bowel disease

> **NIH NIH R21** · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2020 · $184,255

## Abstract

SUMMARY:
The inflammatory bowel diseases (IBD), typically classified as Crohn’s disease (CD) or ulcerative colitis (UC),
are chronic intestinal disorders characterized by dysregulated host immune responses to the gut microbiota in
genetically susceptible hosts. IBD affects 1.4 million people in the United States and it is estimated that the
frequency will continue to increase, resulting in substantial costs related to medical and surgical therapy as well
as lost work productivity, disability, and morbidity for patients. In this proposal, we will develop a sequencing-
based approach to analyze blood and tissue samples from patients with ulcerative colitis in an effort to identify
new determinants involved in the pathogenesis of this disease.

## Key facts

- **NIH application ID:** 9989846
- **Project number:** 5R21DK119724-02
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN DIEGO
- **Principal Investigator:** John T Chang
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $184,255
- **Award type:** 5
- **Project period:** 2019-08-10 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9989846

## Citation

> US National Institutes of Health, RePORTER application 9989846, Using single-cell approaches to study inflammatory bowel disease (5R21DK119724-02). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/9989846. Licensed CC0.

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