# Iron and Heme Core (Core B)

> **NIH NIH U54** · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2020 · $98,268

## Abstract

PROJECT SUMMARY
 
The Iron and Heme Core of the Center for Iron and Heme Disorders (CIHD) will provide analysis of metals,
porphyrins, porphyrin precursors and heme. The Core will measure enzymatic activity of the eight enzymes of
the heme biosynthesis pathway. This Core is unique in the services offered. Analysis and absolute
quantitation of many of these compounds in cells, tissue, whole blood, urine and feces will become available to
laboratories nationally. The Core will also provide a series of reagents, including plasmids for expression of
proteins in heme synthesis, antibodies reactive to these proteins, and unique strains of bacteria that can be
used to purify porphyrin pathway intermediates for use in other experimental systems. Core staff will host
training sessions to assist PIs, post-doctoral fellows and graduate students in performing the services above,
including sessions aimed at data analysis. CIHD investigators will be provided priority access to these
services through dedicated Core staff. It is the goal of the Iron and Heme Core to become a national resource
for the measurement of these enzymes/compounds in a diverse range of experimental systems from bacteria
to human.

## Key facts

- **NIH application ID:** 9990555
- **Project number:** 5U54DK110858-05
- **Recipient organization:** UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH
- **Principal Investigator:** Laurie K Jackson
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $98,268
- **Award type:** 5
- **Project period:** 2016-08-05 → 2021-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9990555

## Citation

> US National Institutes of Health, RePORTER application 9990555, Iron and Heme Core (Core B) (5U54DK110858-05). Retrieved via AI Analytics 2026-06-01 from https://api.ai-analytics.org/grant/nih/9990555. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*